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Life Threatening? No
Write-up: Information has been received regarding a report from a journalist concerning an 18 month old female (also reported as male) who on 11/13/85 was vaccinated with a dose of MMRII. Subsequently, the pt developed sepsis and on 11/18/85, the pt died. The reporter felt that the pt''s sepsis was not related to therapy with MMRII. No further information is available. Follow-up info from a hospital physician indicated that the pt developed fever and vomiting in the afternoon on 11/17/1985. On 11/18/1985, at about three o''xlock, a blue-reddish rash in groins was spreading to generalized. The pt was hosptialized at 4:45 with widespread petechiae and no stiffness of her nek. her LP included: 173 red; 14 white; poly 8, mono6, protein 0.10 and glucose 12. Her cultures included: nasopharynx with much pneumonia and klebsiella: urine -0 and blood-0. Liquor: showed very little growth of meningococcals all sensible to every antibiotic used. The pt received intensive treatment with hydrocortisone sodium succinate and Zinacef, but the pt died at 8:50 on 11/18/1985. Section showed petechiae, swelling of the brain and bilaterally necrosis of adrenal glands. Microscopy showed masive adrenal gland bleeding and surface of cerebrum shows edemic and dry bloody meninges but not meningitis. It was reported that the pt died due to other causes than pharmaceutical and the relationship was incidental. No further info is available.
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