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Found 131 cases where Vaccine is MEN or MENB or MENHIB or MNC or MNQ or MNQHIB and Patient Died and Submission Date on/before '2015-09-30'

Case Details

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VAERS ID: 296530 (history)  
Form: Version 1.0  
Age: 0.6  
Sex: Male  
Location: Foreign  
Vaccinated:2007-10-16
Onset:2007-10-21
   Days after vaccination:5
Submitted: 2007-11-09
   Days after onset:19
Entered: 2007-11-13
   Days after submission:4
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
MNC: MENINGOCOCCAL (MENINGITEC) / PFIZER/WYETH - / 2 UN / IM
PNC: PNEUMO (PREVNAR) / PFIZER/WYETH 25126 / 2 UN / IM

Administered by: Unknown       Purchased by: Unknown
Symptoms: Asphyxia, Atelectasis, Autopsy, Blood test, CSF test, Cardiac arrest, Cough, Death, Dyspnoea, Feeding disorder, Histology, Pneumonia aspiration
SMQs:, Torsade de pointes/QT prolongation (broad), Anaphylactic reaction (narrow), Arrhythmia related investigations, signs and symptoms (broad), Shock-associated circulatory or cardiac conditions (excl torsade de pointes) (narrow), Acute central respiratory depression (broad), Pulmonary hypertension (broad), Hostility/aggression (broad), Cardiomyopathy (broad), Respiratory failure (broad), Infective pneumonia (broad)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 2007-10-21
   Days after onset: 0
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications: Concomitant medications were not reported.
Current Illness:
Preexisting Conditions: The patient previously experienced no adverse drug reaction while taking Meningitec and Prevenar on 31-Aug-2007.
Allergies:
Diagnostic Lab Data: Autopsy (results: No evidence of inflammatory lesions to CNS (in particular to meninges). Macroscopic evaluation of all the organs was within normal range, except for both lungs) was done on 23-Oct-2007. Additionally, the following tests were done on an unspecified date: histology (results: to liver, spleen, heart, thymus, encephalus, cerebellum, thyroid and pancreas within normal range); histology (results: Pulmonary parenchyma with evidence of atelectasis due to the presence of hystiocytes and amorphous material (like little drops of exogenous nature) in the alveolar lumen. Microbial flora and granulocytic inflammatory elements.); blood test (results: waiting for results); and CSF test (results: waiting for results). The cause of death was reported as cardiac arrest and the autopsy cause of death was asphyxia and aspiration pneumonia.
CDC Split Type: ITWYEG00560207

Write-up: Follow-up information concerning change of adverse events and results of autopsy has been received and incorporated into the narrative. Information regarding Meningitec was received from a healthcare professional via a regulatory authority regarding a 7-month-old male patient who experienced cardiac arrest, asphyxia, aspiration pneumonia and milk went down the wrong way. The patient received the second dose on 16-OCT-2007. The patient also received the second dose of Prevenar on 16-Oct-2007. The patient experienced cardiac arrest, asphyxia, aspiration pneumonia and milk went down the wrong way on 21-Oct-2007 showing cough and ingravescent and acute dyspnoea. The outcome of the events was reported as fatal. No additional information was available at the time of this report.


VAERS ID: 326382 (history)  
Form: Version 1.0  
Age:   
Sex: Unknown  
Location: Foreign  
Vaccinated:0000-00-00
Onset:0000-00-00
Submitted: 2008-09-26
Entered: 2008-09-29
   Days after submission:3
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
DTAP: DTAP (NO BRAND NAME) / UNKNOWN MANUFACTURER - / UNK UN / UN
HIBV: HIB (NO BRAND NAME) / UNKNOWN MANUFACTURER - / UNK UN / UN
MEN: MENINGOCOCCAL (NO BRAND NAME) / UNKNOWN MANUFACTURER - / UNK UN / UN
OPV: POLIO VIRUS, ORAL (NO BRAND NAME) / UNKNOWN MANUFACTURER - / UNK MO / PO

Administered by: Unknown       Purchased by: Unknown
Symptoms: Anaemia, Cardiac failure, Death, Feeding disorder, Haemoglobin decreased, Histiocytosis haematophagic, Irritability
SMQs:, Cardiac failure (narrow), Haematopoietic erythropenia (broad), Haemorrhage laboratory terms (broad), Noninfectious encephalitis (broad), Noninfectious encephalopathy/delirium (broad), Noninfectious meningitis (broad), Hostility/aggression (broad), Cardiomyopathy (broad), Hypoglycaemia (broad)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 0000-00-00
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications:
Current Illness:
Preexisting Conditions: None reported.
Allergies:
Diagnostic Lab Data: Haemoglobin, 4.5 g/dl
CDC Split Type: E200808724

Write-up: This case was initially reported to SPMSD by the health authority on 18-Sep-2008. ADR 20313410. This case was identified in the following literature article; This case concerns an infant of unknown age and gender. The patient received DTP vaccine, Hib vaccine, meningococcal C vaccine and oral poliomyelitis vaccine, manufacturers and batch numbers not reported, on an unreported date. On an unreported date, one day post vaccination, the patient arrested. The patient had developed difficulty in feeding and had been irritable for six hours previously. Post mortem results showed haemophagocytosis in the spleen and bone marrow which was responsible for a low haemoglobin of 4.5g/dl. The anaemia had induced cardiac failure. The cause of death was reported by the MHRA as cardiac failure and haemophagocytosis. The outcome of the events of difficulty in feeding, irritability and anaemia were unknown. Case is closed. The cause of death in this case was haemophagocytosis leading to anemia and cardiac failure. Haemophagocytosis is an unusual syndrome characterized by fever, splenomegaly, jaundice, and the pathological finding of haemophagocytosis in bone marrow and other tissues. This could be genetic or acquired. Acquired disease has no known underlying immune deficiency. Both acquired and genetic forms are triggered by infections, mostly viruses, other stimuli. The cause was not determined in this case. Events reported one day post vaccination i.e. irritability and difficulty in feed are known symptoms of this disease. Administration of vaccine seems co-incidental.


VAERS ID: 384961 (history)  
Form: Version 1.0  
Age: 1.0  
Sex: Unknown  
Location: Foreign  
Vaccinated:0000-00-00
Onset:0000-00-00
Submitted: 2010-04-12
Entered: 2010-04-13
   Days after submission:1
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
HIBV: HIB (PEDVAXHIB) / MERCK & CO. INC. - / UNK UN / UN
MEN: MENINGOCOCCAL (NO BRAND NAME) / UNKNOWN MANUFACTURER - / UNK UN / UN
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. - / UNK UN / UN

Administered by: Unknown       Purchased by: Unknown
Symptoms: Brain oedema, Death, Encephalitis
SMQs:, Noninfectious encephalitis (narrow), Hyponatraemia/SIADH (broad), Haemodynamic oedema, effusions and fluid overload (narrow), Drug reaction with eosinophilia and systemic symptoms syndrome (broad)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 0000-00-00
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications:
Current Illness:
Preexisting Conditions: Unknown
Allergies:
Diagnostic Lab Data: Unknown
CDC Split Type: WAES1004USA00762

Write-up: Information has been received from a published article. The report summarizes passive surveillance data for adverse events following immunisation (AEFI) reported for 2008, and describes reporting trends over the 9-year period 2000 to 2008. It reported death of a 12 month old patient who had PEDVAXHIB (manufacturer unknown) (lot number not reported), meningococcal C and MMR II (Lot number not reported). The cause of death was reported to be cerebral oedema due to encephalitis 12 days after receipt of the vaccine, with onset of illness 10 days after vaccination. According to the treating neurologist and pediatrician it was unlikely to be vaccine related. Upon internal review, encephalitis was considered to be an other important medical event. Additional information is not expected. The article also discussed the experience of a patient while vaccinated with varicella vaccine. (WAES #1004USA00761). A copy of the published article is attached as further documentation of the patient''s experience.


VAERS ID: 387747 (history)  
Form: Version 1.0  
Age: 3.0  
Sex: Female  
Location: Foreign  
Vaccinated:2010-03-25
Onset:2010-03-25
   Days after vaccination:0
Submitted: 2010-05-18
   Days after onset:54
Entered: 2010-05-18
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
DTPHIB: DTP + HIB (NO BRAND NAME) / UNKNOWN MANUFACTURER - / UNK UN / UN
IPV: POLIO VIRUS, INACT. (NO BRAND NAME) / UNKNOWN MANUFACTURER - / UNK UN / UN
MEN: MENINGOCOCCAL (NO BRAND NAME) / UNKNOWN MANUFACTURER - / UNK UN / UN
RVX: ROTAVIRUS (NO BRAND NAME) / UNKNOWN MANUFACTURER - / UNK UN / UN

Administered by: Other       Purchased by: Other
Symptoms: Bacterial infection, Blood culture negative, CSF culture positive, Death, Fontanelle bulging, Gram stain positive, Pneumonia pneumococcal, Pyrexia, Streptococcus test positive, Vomiting
SMQs:, Acute pancreatitis (broad), Neuroleptic malignant syndrome (broad), Anticholinergic syndrome (broad), Gastrointestinal nonspecific symptoms and therapeutic procedures (narrow), Neonatal disorders (narrow), Drug reaction with eosinophilia and systemic symptoms syndrome (broad), Infective pneumonia (narrow)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 0000-00-00
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? Yes, 0 days
   Extended hospital stay? No
Previous Vaccinations:
Other Medications:
Current Illness: Unknown
Preexisting Conditions:
Allergies:
Diagnostic Lab Data: Blood culture, 2010, Negative; CSF culture, 2010, see text
CDC Split Type: B0652265A

Write-up: This case was reported by a physician and described the occurrence of cause unknown, death in a 3-year-old female subject who was vaccinated with meningococcal polysaccharide vaccine group C (manufacturer unspecified), DTP-HIB (A or W not known), poliomyelitis vaccine unspecified and rotavirus vaccine. On 25 March 2010, the subject received unspecified dose of Meningococcal polysaccharide vaccine group C (unknown route of administration, lot number not provided), unspecified dose of DTP-HIB (A or W not known) (unknown route of administration, lot number not provided), unspecified dose of Poliomyelitis vaccine (unknown route of administration, lot number not provided), unspecified dose of Rotavirus vaccine (unknown route of administration, lot number not provided). The physician informed that the subject was not healthy at the time of vaccination, but she couldn''t provide details about the subject''s clinical condition. On 25 March 2010, 10 hours after vaccination with DTP-HIB (A or W not known), Meningococcal polysaccharide vaccine group C, Poliomyelitis vaccine and Rotavirus vaccine, the subject experienced fever (not specified), vomiting and bulging fontanel. The subject was hospitalised and evolved to death. Purulent CSF; CSF culture: streptococcus pneumoniae positive; Blood culture: negative; Blood gram: diplococcus gram positive. The subject died, cause of death is not specified. It was unknown whether an autopsy was performed. The physician couldn''t state if the event was related to the vaccines, because the case was still under investigation.


VAERS ID: 390076 (history)  
Form: Version 1.0  
Age: 1.3  
Sex: Female  
Location: Foreign  
Vaccinated:0000-00-00
Onset:0000-00-00
Submitted: 2010-06-04
Entered: 2010-06-07
   Days after submission:3
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
MEN: MENINGOCOCCAL (NO BRAND NAME) / UNKNOWN MANUFACTURER VNS1H02B / UNK UN / UN
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. 0392Y / UNK UN / UN

Administered by: Unknown       Purchased by: Unknown
Symptoms: Death
SMQs:

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 0000-00-00
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications: Unknown
Current Illness:
Preexisting Conditions: Unknown
Allergies:
Diagnostic Lab Data: Unknown
CDC Split Type: WAES1006USA00473

Write-up: Information has been received from a physician-epidemiologist on 01-JUN-2010 under the reference number RIVM20100619. A 16-month-old female patient had received a dose of MMR II (LOT # 664460/0392Y, batch # NL03720) and NEISVAC-C (manufacturer Baxter, lot VNS1H02B) on an unknown date. Eleven days after the vaccination, the patient passed away. No information on medical history reported. Precise circumstances not known at the time of reporting (case reported to health agency on 28-MAY-2010 afternoon). Health agency will investigate upon this case as usual. A lot check has been initiated. Other business partner numbers included: E2010-03420. No further information is available.


VAERS ID: 390134 (history)  
Form: Version 1.0  
Age: 1.0  
Sex: Unknown  
Location: Foreign  
Vaccinated:0000-00-00
Onset:0000-00-00
Submitted: 2010-06-07
Entered: 2010-06-07
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
HIBV: HIB (NO BRAND NAME) / UNKNOWN MANUFACTURER - / UNK UN / UN
MEN: MENINGOCOCCAL (NO BRAND NAME) / UNKNOWN MANUFACTURER - / UNK UN / UN
MMR: MEASLES + MUMPS + RUBELLA (NO BRAND NAME) / UNKNOWN MANUFACTURER - / UNK UN / UN

Administered by: Other       Purchased by: Other
Symptoms: Brain oedema, Death, Encephalitis
SMQs:, Noninfectious encephalitis (narrow), Hyponatraemia/SIADH (broad), Haemodynamic oedema, effusions and fluid overload (narrow), Drug reaction with eosinophilia and systemic symptoms syndrome (broad)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 0000-00-00
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications:
Current Illness: Unknown
Preexisting Conditions:
Allergies:
Diagnostic Lab Data: UNK
CDC Split Type: B0658324A

Write-up: This case was reported in a literature article and described the occurrence of cerebral edema in a 1-year-old child who was vaccinated with HIB (manufacturer unspecified), MMR (strain not specified), MMR II, strain not specified and MENINGITIS C. On an unspecified date the subject received unspecified dose of HIB (unknown), unspecified dose of MMR (unknown), unspecified dose of MENINGITIS C (unknown). Ten days after vaccination with HIB, MMR and MENINGITIS C vaccinations, the subject onset the illness. Twelve days after vaccination the subject died. The cause of death was reported to be cerebral edema due to encephalitis. The author considered the events were unlikely to be related to vaccination with HIB, MMR and MENINGITIS C vaccination.


VAERS ID: 414458 (history)  
Form: Version 1.0  
Age: 1.0  
Sex: Unknown  
Location: Foreign  
Vaccinated:2010-12-01
Onset:0000-00-00
Submitted: 2011-01-10
Entered: 2011-01-11
   Days after submission:1
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
MEN: MENINGOCOCCAL (NO BRAND NAME) / UNKNOWN MANUFACTURER - / UNK UN / UN
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. - / UNK UN / UN

Administered by: Unknown       Purchased by: Unknown
Symptoms: Autopsy, Death
SMQs:

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 0000-00-00
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications: Unknown
Current Illness:
Preexisting Conditions: Unknown
Allergies:
Diagnostic Lab Data: Unknown
CDC Split Type: WAES1101USA00059

Write-up: Case of fatal outcome received from a healthcare professional on 28-DEC-2010. This case is poorly documented. Case medically confirmed. A 12 month old patient had received a dose of MMR II (Lot # not reported) on an unspecified date in December 2010. Concomitantly, the patient was vaccinated with a dose of MENINGITEC (Lot # not reported). Subsequently, (exact latency not reported), the patient died. An autopsy was performed and reportedly, no pathologic alterations were found. It was assumed that the child died from sudden infant death syndrome. Other business partner numbers include E2010-080500. No further information is available.


VAERS ID: 417993 (history)  
Form: Version 1.0  
Age: 1.17  
Sex: Male  
Location: Foreign  
Vaccinated:2008-01-21
Onset:0000-00-00
Submitted: 2011-03-03
Entered: 2011-03-04
   Days after submission:1
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
MEN: MENINGOCOCCAL (NO BRAND NAME) / UNKNOWN MANUFACTURER VNS1A03C / UNK UN / UN
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. 0446F / 1 UN / UN

Administered by: Unknown       Purchased by: Unknown
Symptoms: Death, Otitis media, Respiratory tract infection bacterial, Sepsis
SMQs:, Infective pneumonia (broad), Sepsis (narrow)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 2008-02-03
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? Yes, ? days
   Extended hospital stay? No
Previous Vaccinations:
Other Medications: Unknown
Current Illness:
Preexisting Conditions: Unknown
Allergies:
Diagnostic Lab Data: Unknown
CDC Split Type: WAES1102USA03642

Write-up: Case of fatal outcome received from the health authorities (Lareb) on 25-FEB-2011 under the reference number NL-LRB-117632 (reference number: RIVM201001397). Case medically confirmed. Initial source was a physician. Case reported as serious by the Lareb (criterion: death, hospitalization). Upon internal review, the company added the following seriousness criterion: Other medically important event (septicaemia). A 12 month (1 year) old male patient had received the first 0.5 ml dose of MMR II (also reported as rHA) (Batch# NE03580; Lot# 653951/0446F) and a 0.5 ml dose of NEISVAC-C (Lot# VNS1A03C) on 21-JAN-2008. There was no information reported on medical history and on concomitant medication. The patient experienced otitis media, respiratory tract infection bacterial and septicaemia. No latency was reported. The adverse events were respectively reported with the following outcomes: "not recovered", "fatal" and "fatal". All MedDRA LLT have "primary source reaction: death 13 days after the vaccination" (i.e. death on 03-FEB-2008). Other business partner number included E2011-01248. A lot check has been initiated. Additional information is not expected.


VAERS ID: 435637 (history)  
Form: Version 1.0  
Age: 61.0  
Sex: Female  
Location: Foreign  
Vaccinated:0000-00-00
Onset:0000-00-00
Submitted: 2011-09-13
Entered: 2011-09-22
   Days after submission:9
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
MEN: MENINGOCOCCAL (NO BRAND NAME) / UNKNOWN MANUFACTURER - / UNK UN / IJ
PPV: PNEUMO (NO BRAND NAME) / UNKNOWN MANUFACTURER - / UNK UN / IJ

Administered by: Other       Purchased by: Other
Symptoms: Abdominal pain, Abdominal pain upper, Abdominal rigidity, Abdominal tenderness, Acute abdomen, Biopsy bronchus abnormal, Biopsy lung, Bronchoscopy abnormal, C-reactive protein increased, Chemotherapy, Chest pain, Computerised tomogram abdomen abnormal, Computerised tomogram abnormal, Computerised tomogram thorax abnormal, Conjunctival pallor, Death, Dizziness, Gastrointestinal sounds abnormal, Haemoglobin decreased, Histology abnormal, Intensive care, Laparotomy, Lung adenocarcinoma stage IV, Lung consolidation, Lung neoplasm malignant, Lymphadenopathy mediastinal, Malaise, Mechanical ventilation, Metastases to bone, Metastasis, Muscle rigidity, Musculoskeletal pain, Neutrophil count increased, Non-small cell lung cancer metastatic, Palliative care, Pallor, Pleural effusion, Pulmonary hilum mass, Rales, Shock, Splenic haematoma, Splenic haemorrhage, Splenic rupture, Surgery, Transfusion, Vomiting, White blood cell count increased
SMQs:, Rhabdomyolysis/myopathy (broad), Anaphylactic reaction (narrow), Acute pancreatitis (broad), Haematopoietic erythropenia (broad), Haemorrhage terms (excl laboratory terms) (narrow), Haemorrhage laboratory terms (broad), Neuroleptic malignant syndrome (broad), Systemic lupus erythematosus (broad), Anticholinergic syndrome (broad), Retroperitoneal fibrosis (broad), Shock-associated circulatory or cardiac conditions (excl torsade de pointes) (narrow), Hypovolaemic shock conditions (narrow), Toxic-septic shock conditions (narrow), Anaphylactic/anaphylactoid shock conditions (narrow), Hypoglycaemic and neurogenic shock conditions (narrow), Malignancy related therapeutic and diagnostic procedures (narrow), Parkinson-like events (narrow), Gastrointestinal perforation, ulcer, haemorrhage, obstruction non-specific findings/procedures (broad), Acute central respiratory depression (broad), Accidents and injuries (narrow), Gastrointestinal nonspecific symptoms and therapeutic procedures (narrow), Haemodynamic oedema, effusions and fluid overload (narrow), Cardiomyopathy (broad), Vestibular disorders (broad), Conjunctival disorders (narrow), Hypotonic-hyporesponsive episode (broad), Hypersensitivity (narrow), Respiratory failure (broad), Tendinopathies and ligament disorders (broad), Drug reaction with eosinophilia and systemic symptoms syndrome (narrow), Non-haematological malignant tumours (narrow), Infective pneumonia (broad)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 0000-00-00
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications: penicillin V
Current Illness: Malaise; Dizziness; Vomiting; Chest pain; Musculoskeletal pain; Tobacco User, Approximately 40 pack per year; Blood pressure decreased; Abdominal pain upper; C-reactive protein increased; Acute abdomen, Generalized abdominal tenderness with guarding, rigidity and absent bowel sounds, consistent with an acute abdomen; Pallor; Haemoglobin decreased; Splenic rupture; Conjunctival pallor; Haemorrhage
Preexisting Conditions: Computerised tomogram abnormal, Computer tomography scan of her thorax and abdomen, which showed a left hilar mass with extensive mediastinal adenopathy, bibasal small effusions and consolidation, and a large splenic hematoma with high attenuation suggestive of active bleeding. There was a lytic area affecting her T9 vertebra, which likely represented metastases rather than wedge fracture; Laparotomy, On examination of her internal organs at laparotomy, other than hemorrhage and rupture of her spleen, there was no other gross abnormality and no evidence of disease in her other intra-abdominal organs
Allergies:
Diagnostic Lab Data: Biopsy bronchus, Significant, Confirmed invasive adenocarcinoma; Bronchoscopy, Significant, Trans bronchial needle aspiration revealed numerous malignant nodes consistent with non-small cell carcinoma; Computerised tomogram abnormal, Significant, Bone metastases found on CT
CDC Split Type: PHHY2011GB80735

Write-up: Case number PHHY2011GB80735 is an initial literature report received on 08 Sep 2011: The authors presented a case of acute abdomen due to spontaneous splenic rupture (SSR) as the first presentation of lung malignancy. This case refers to a 61-year-old female patient. There was nothing in the history to suggest a recent viral or other infective process including human immunodeficiency virus or acquired immune deficiency state and no history of any trauma or injury. She had no significant previous medical or surgical history and was not taking any medications. There was no background or family history of cancer, hematologic or clotting disorders. She was a smoker of approximately 40 pack per year and had unlimited exercise tolerance. She presented with a three day history of feeling generally unwell with dizziness, vomiting, abdominal, left lower chest pain and shoulder pain and hospitalized. She denied any sore throat, feeling feverish or other symptoms suggestive of an influenza-like illness. She was ill-looking, conscious and orientated with a blood pressure 89/49mmHg, heart rate of 72 beats per minute, saturations 97% on a non-rebreather mask and temperature of 36.9 degree Celsius. The admission examination revealed normal cardiac examination and bibasal inspiratory crepitations with left upper quadrant and epigastric tenderness on abdominal examination. Her blood work-up on admission showed a hemoglobin level of 11.4g/L, white blood cell count of 19*10^9/L with neutrophils of 17*10^9/L and a C-reactive protein of 7mg/L. Hemodynamic stability was achieved following rehydration with intravenous fluids. However eight hours after admission into the hospital, she developed an acute abdomen with clinical signs of shock. Her blood pressure was 88/52mmHg and heart rate 105 beats per minute. Further to that her oxygen saturations were 91%. Inspection revealed skin and conjunctival pallor. Clinical examination revealed new abdominal signs of generalized abdominal tenderness with guarding, rigidity and absent bowel sounds, consistent with an acute abdomen. A repeat test showed her hemoglobin level had dropped to 5.0g/L. She was stabilized with multiple blood transfusions and underwent an urgent computer tomography scan of her thorax and abdomen, which showed a left hilar mass with extensive mediastinal adenopathy, bibasal small effusions and consolidation, and a large splenic hematoma with high attenuation suggestive of active bleeding. There was a lytic area affecting her T9 vertebra, which likely represented metastases rather than wedge fracture, but there were no abnormalities or neoplastic disease affecting the intra-abdominal organs. She was vaccinated with meningococcal vaccine (manufacturer and batch number: unknown) and pneumococcal vaccine (manufacturer and batch number: unknown) on an unspecified date. She was then promptly taken for laparotomy. On examination of her internal organs at laparotomy, other than hemorrhage and rupture of her spleen, there was no other gross abnormality and no evidence of disease in her other intra-abdominal organs. She spent two days being ventilated in intensive care unit and subsequently made a fully recover from the surgery. She was commenced on life-long penicillin V and was subsequently discharged home a week after admission, fully mobile and independent in terms of her activities of daily living. Her splenic histology was negative for hematologic or other malignancy and no other pathology was identified. She then underwent a bronchoscopy; trans bronchial needle aspiration revealed numerous malignant nodes consistent with non-small cell carcinoma. Histology of bronchial biopsies confirmed invasive adenocarcinoma. This was consistent with likely stage IV in view of the likely bone metastases found on CT. She was referred to the local oncologist. In view of the diagnosis and staging, a palliative treatment pathway was agreed from the outset and she received palliative chemotherapy. She died five months after her presentation., It was possible that this patient had two concurrent, unrelated pathologies: bronchial adenocarcinoma and a true SSR. However, given the well-described association between neoplastic disease and SSR, this case reports linking the two conditions and the rarity of true spontaneous splenic rupture, it was likely that the two conditions were linked with the former precipitating the latter. The authors concluded that lung cancer could potentially precipitate SSR; it could even present itself as SSR as in this patient.


VAERS ID: 444081 (history)  
Form: Version 1.0  
Age: 15.0  
Sex: Female  
Location: Foreign  
Vaccinated:0000-00-00
Onset:0000-00-00
Submitted: 2011-11-30
Entered: 2011-11-30
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
MNQ: MENINGOCOCCAL CONJUGATE (MENVEO) / NOVARTIS VACCINES AND DIAGNOSTICS - / UNK UN / IJ

Administered by: Other       Purchased by: Other
Symptoms: Abdominal pain, Blood culture positive, Death, Depressed level of consciousness, Haemodynamic instability, Infection in an immunocompromised host, Intensive care, Meningococcal sepsis, Neisseria test positive, Pyrexia
SMQs:, Acute pancreatitis (broad), Hyperglycaemia/new onset diabetes mellitus (broad), Neuroleptic malignant syndrome (broad), Anticholinergic syndrome (broad), Retroperitoneal fibrosis (broad), Noninfectious encephalitis (broad), Noninfectious encephalopathy/delirium (broad), Noninfectious meningitis (broad), Gastrointestinal nonspecific symptoms and therapeutic procedures (narrow), Hypotonic-hyporesponsive episode (broad), Generalised convulsive seizures following immunisation (broad), Drug reaction with eosinophilia and systemic symptoms syndrome (broad), Hypoglycaemia (broad), Sepsis (narrow)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 0000-00-00
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications: mycophenolate; prednisone
Current Illness: systemic lupus erythematosus
Preexisting Conditions:
Allergies:
Diagnostic Lab Data: blood culture, significant, NmX was isolated in the blood cultures
CDC Split Type: PHHY2011ES103853

Write-up: Case number PHHY2011ES103853 is an initial spontaneous report received on 24 Nov 2011: The authors have analyzed a case of invasive meningococcal disease due to Neisseria meningitidis serogroup X (NmX) sepsis in an immunocompromised patient. This report refers to a 15-year-old female patient. She was diagnosed with systemic lupus erythematosus In 2005 and was receiving mycophenolate (an immunosuppressor that inhibited inosine monophosphate dehydrogenase) and oral prednisone (40 mg/day). She was vaccinated with MENVEO INN (manufacturer and batch number was unknown) on an undetermined date. She did not receive any antibiotic prophylaxis during immunosuppressive therapy. After vaccination she developed invasive meningococcal disease due to NmX. She presented to the hospital with fever and abdominal pain on an unspecified date after vaccination. A few hours later, lowering of the level of consciousness and abrupt hemodynamic deterioration were observed. The patient died in less than 24 hours, despite support measures in the intensive care unit (ICU). NmX was isolated in the blood cultures of this patient. Later on, it was identified that, these isolated causing fatal episodes belonged to the ST-750 clonal complex. The authors concluded that foreseeable frequent use of conjugate meningococcal vaccine for serogroups A, C, Y and W135, with a powerful effect on pharyngeal carriage could favor the dissemination of serogroup X strains.


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