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Found 478 cases where Vaccine targets Measles (MEA or MER or MM or MMR or MMRV) and Patient Died and Vaccination Date on/before '2018-11-30'

Case Details

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VAERS ID: 674054 (history)  
Form: Version 1.0  
Age: 1.25  
Sex: Male  
Location: Georgia  
Vaccinated:2016-11-29
Onset:2016-12-09
   Days after vaccination:10
Submitted: 2016-12-21
   Days after onset:12
Entered: 2016-12-21
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. M010426 / 1 LA / SC
VARCEL: VARICELLA (VARIVAX) / MERCK & CO. INC. M025864 / 1 RA / SC

Administered by: Unknown       Purchased by: Private
Symptoms: Acute respiratory distress syndrome, Death, Endotracheal intubation, Enterovirus test positive, Extracorporeal membrane oxygenation, Human metapneumovirus test positive, Pyrexia, Respiratory distress, Upper respiratory tract infection
SMQs:, Anaphylactic reaction (broad), Angioedema (broad), Interstitial lung disease (broad), Neuroleptic malignant syndrome (broad), Anticholinergic syndrome (broad), Acute central respiratory depression (broad), Guillain-Barre syndrome (broad), Eosinophilic pneumonia (broad), Hypersensitivity (broad), Respiratory failure (narrow), Drug reaction with eosinophilia and systemic symptoms syndrome (broad), Infective pneumonia (broad), Opportunistic infections (broad)

Life Threatening? Yes
Birth Defect? No
Died? Yes
   Date died: 2016-12-18
   Days after onset: 9
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? Yes
ER or Doctor Visit? No
Hospitalized? Yes, 7 days
   Extended hospital stay? No
Previous Vaccinations:
Other Medications: Augmentin
Current Illness: Had hand, foot mouth and OM diagnosed 11/21 - on Augmentin. No symptoms on 11/29 other than candida diaper rash
Preexisting Conditions:
Allergies:
Diagnostic Lab Data: Human metapneumovirus, enterovirus positive
CDC Split Type:

Write-up: Had URI, fever, developed respiratory distress, intubated in ER, ARDS ECMO, coded x2 died 12/18/2016.


VAERS ID: 682123 (history)  
Form: Version 1.0  
Age: 4.0  
Sex: Male  
Location: New York  
Vaccinated:2017-02-01
Onset:2017-02-02
   Days after vaccination:1
Submitted: 2017-02-10
   Days after onset:8
Entered: 2017-02-10
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
DTAPIPV: DTAP + IPV (KINRIX) / GLAXOSMITHKLINE BIOLOGICALS 434B3 / 2 UN / UN
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. M017347 / 2 UN / UN
VARCEL: VARICELLA (VARIVAX) / MERCK & CO. INC. M036293 / 2 UN / UN

Administered by: Public       Purchased by: Other
Symptoms: Condition aggravated, Hypotension, Multiple organ dysfunction syndrome, Pyrexia, Seizure, Shock, Status epilepticus
SMQs:, Torsade de pointes/QT prolongation (broad), Anaphylactic reaction (narrow), Neuroleptic malignant syndrome (broad), Systemic lupus erythematosus (broad), Anticholinergic syndrome (broad), Shock-associated circulatory or cardiac conditions (excl torsade de pointes) (narrow), Torsade de pointes, shock-associated conditions (broad), Hypovolaemic shock conditions (narrow), Toxic-septic shock conditions (narrow), Anaphylactic/anaphylactoid shock conditions (narrow), Hypoglycaemic and neurogenic shock conditions (narrow), Convulsions (narrow), Noninfectious encephalitis (broad), Noninfectious encephalopathy/delirium (broad), Noninfectious meningitis (broad), Hypotonic-hyporesponsive episode (broad), Generalised convulsive seizures following immunisation (narrow), Hypersensitivity (narrow), Drug reaction with eosinophilia and systemic symptoms syndrome (broad), Hypoglycaemia (broad), Dehydration (broad), Hypokalaemia (broad), Sepsis (broad)

Life Threatening? Yes
Birth Defect? No
Died? Yes
   Date died: 2017-02-20
   Days after onset: 18
Permanent Disability? Yes
Recovered? No
Office Visit? No
ER Visit? Yes
ER or Doctor Visit? No
Hospitalized? Yes, 17 days
   Extended hospital stay? No
Previous Vaccinations:
Other Medications: ONFI; TRILEPTAL
Current Illness: None
Preexisting Conditions: epilepsy; autism; microcephaly
Allergies:
Diagnostic Lab Data:
CDC Split Type:

Write-up: 4 year old boy with complicated medical condition-autism, seizure disorder, microcephaly - received 4 year old vaccines at regular check up. Was in good health at the visit. Following day, had a fever, then began having seizures -$g status epilepticus later admitted to hospital where he went into hypotensive shock and multi organ failure. Currently in critical condition.


VAERS ID: 694117 (history)  
Form: Version 1.0  
Age:   
Sex: Male  
Location: Georgia  
Vaccinated:0000-00-00
Onset:0000-00-00
Submitted: 2017-05-12
Entered: 2017-05-12
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. - / UNK UN / UN

Administered by: Other       Purchased by: Unknown
Symptoms: Death, Seizure
SMQs:, Systemic lupus erythematosus (broad), Convulsions (narrow), Noninfectious encephalitis (broad), Noninfectious encephalopathy/delirium (broad), Noninfectious meningitis (broad), Generalised convulsive seizures following immunisation (narrow), Hypoglycaemia (broad)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 0000-00-00
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications:
Current Illness:
Preexisting Conditions:
Allergies:
Diagnostic Lab Data:
CDC Split Type: US0095075131705USA005362

Write-up: This spontaneous report was received from a physician via a company representative and refers to a male child patient. The patient''s concurrent conditions, medical history and concomitant therapies were not reported. Approximately in 1997 (reported as "about 20 years"), the patient was vaccinated with a dose of M-M-R II frequency reported as "one injection", parenteral route reported as "injection" (anatomical place of vaccination was not provided), for Measles, Mumps, and Rubella prophylaxis. Approximately in 1997 (reported as "two weeks after the vaccine was administered"), the patient experienced seizures and for an unspecified reason and the child passed away (death), subsequently on an unspecified date, the child passed away for an unspecified reason. At the time of reporting, the outcome of seizure was unknown. The reporter did not provide a causality assessment between M-M-R II, seizures and death. Upon internal review, seizures and the death were determined to be medically significant. Additional information is not expected, as the reporter did not provide consent to follow up.


VAERS ID: 703833 (history)  
Form: Version 2.0  
Age: 3.0  
Sex: Male  
Location: New York  
Vaccinated:2017-01-16
Onset:0000-00-00
Submitted: 0000-00-00
Entered: 2017-07-16
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
DTAPIPV: DTAP + IPV (KINRIX) / GLAXOSMITHKLINE BIOLOGICALS Y2N22 / 1 UN / UN
MMRV: MEASLES + MUMPS + RUBELLA + VARICELLA (PROQUAD) / MERCK & CO. INC. M038227 / 2 LA / SYR

Administered by: Private       Purchased by: ?
Symptoms: Autopsy, Death
SMQs:

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 2017-02-01
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications: NONE
Current Illness: CRANIOSYNOSTOSIS AT BIRTH
Preexisting Conditions:
Allergies: NONE
Diagnostic Lab Data: AUTOPSY
CDC Split Type:

Write-up: DEATH.


VAERS ID: 763982 (history)  
Form: Version 2.0  
Age: 2.0  
Sex: Female  
Location: Unknown  
Vaccinated:1997-12-12
Onset:2018-07-06
   Days after vaccination:7511
Submitted: 0000-00-00
Entered: 2018-08-06
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. - / 1 UN / SC

Administered by: Unknown       Purchased by: ?
Symptoms: Asthenia, Fatigue, Joint swelling, Measles antibody negative
SMQs:, Guillain-Barre syndrome (broad), Haemodynamic oedema, effusions and fluid overload (narrow), Arthritis (broad), Tendinopathies and ligament disorders (broad)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 0000-00-00
Permanent Disability? No
Recovered? No
Office Visit? Yes
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications:
Current Illness: Egg allergy (Has become less severe over time); Milk allergy (Has become less severe over time)
Preexisting Conditions:
Allergies:
Diagnostic Lab Data:
CDC Split Type: US0095075131807USA011635

Write-up: This spontaneous report was received from the patient''s mother, concerning a 2 year old female patient. The patient did not have any medical history to report. Her concurrent conditions included allergy to dairy and egg. The patient did not have any concomitant medications to report. On 12-DEC-1997, the patient was vaccinated with the first dose of M-M-R II subcutaneously for prophylaxis lot #0015E (strength, dose, frequency and expiration date were not reported). On the same date, 3 hours after receiving the vaccination with M-M-R II, the patient began to experiencing a severe reaction including joint swelling, fatigue and generalized weakness. The patient sought for medical attention and was treated with prednisolone sodium phosphate (PEDIAPRED) liquid and a 6 day steroid regimen. On an unknown date, the patient recovered from joint swelling. On an unknown date in March 2001, the patient received a second "graduated dose style" of M-M-R II subcutaneously for prophylaxis (strength, dose, frequency, lot number and expiration date were not reported). The patient did not have any reaction following this administration. On 06-JUL-2018, when the patient was 22 year old, the patient had a measles titer test performed and it was failed, there was no immunity. On an unknown date, approximately in 2018, the patient died. It was unknown if an autopsy was performed. At the time of reporting, the outcome of fatigue, generalized weakness, measles titer failed and no immunity was unknown. The causal relationship between the vaccination with M-M-R II and the events was not provided by the reporter.; Reported Cause(s) of Death: Did the patient died: yes.


VAERS ID: 774823 (history)  
Form: Version 2.0  
Age:   
Sex: Male  
Location: Unknown  
Vaccinated:0000-00-00
Onset:0000-00-00
Submitted: 0000-00-00
Entered: 2018-10-01
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
HEP: HEP B (NO BRAND NAME) / UNKNOWN MANUFACTURER - / UNK UN / UN
HEPA: HEP A (NO BRAND NAME) / UNKNOWN MANUFACTURER - / UNK UN / UN
HIBV: HIB (NO BRAND NAME) / UNKNOWN MANUFACTURER - / UNK UN / UN
MMR: MEASLES + MUMPS + RUBELLA (NO BRAND NAME) / UNKNOWN MANUFACTURER - / UNK UN / UN
PPV: PNEUMO (NO BRAND NAME) / UNKNOWN MANUFACTURER - / UNK UN / UN

Administered by: Other       Purchased by: ?
Symptoms: Death, Laboratory test normal, Pyrexia, Toxicologic test normal, Viral myocarditis
SMQs:, Neuroleptic malignant syndrome (broad), Anticholinergic syndrome (broad), Cardiomyopathy (broad), Drug reaction with eosinophilia and systemic symptoms syndrome (broad), Opportunistic infections (broad)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 0000-00-00
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications:
Current Illness:
Preexisting Conditions: Medical History/Concurrent Conditions: Allergic rhinitis; Eczema
Allergies:
Diagnostic Lab Data:
CDC Split Type: ITSA2018SA268144

Write-up: Initial unsolicited report received from the literature on 22-Sep-2018. This case is linked to cases 2018SA268028, 2018SA268912, 2018SA268046, 2018SA268054, 2018SA268066, 2018SA268077, 2018SA268091, 2018SA268096, 2018SA268116, 2018SA268136, 2018SA268154, 2018SA268180, 2018SA268794, 2018SA268803, 2018SA268809, 2018SA268813, 2018SA268832, 2018SA268839, 2018SA268849, 2018SA268859, 2018SA268864, 2018SA268872, 2018SA268876, 2018SA268889, 2018SA268901, 2018SA268907, 2018SA268912, 2018SA268929, 2018SA268936, 2018SA268946, 2018SA268957, 2018SA268965, 2018SA268974, 2018SA268988, 2018SA268995, 2018SA269004 and 2018SA269014. Abstract: Aim: To characterize cases of myocarditis (MC) and pericarditis (PC) recorded in the Vaccine Adverse Event Reporting System (VAERS). Methods: Cases were extracted from VAERS (2011-2015) and assessed for causality using standardized WHO algorithm. Disproportionality analysis was performed through reporting odds ratio (ROR) with 95% CI. MEDLINE was also searched. Results: In VAERS, 199 cases of MC or PC were collected, among which 149 reported smallpox vaccine. The remaining were: 15 cases in ''YOUNGER GROUP'' (YG; b18 years old) and 35 in ''OLDER GROUP'' (OG; N18 years old). Main reported vaccines were against Human Papilloma Virus (n = 6) in YG and influenza (n = 16) in OG. Causality always resulted "undeterminate" for YG, whereas either "undetermined" (30 cases) and "correlated" (3 cases) for OG. Statistically significant ROR was found in YG for meningococcal vaccine (ROR = 3.55; 95%CI = 1.23-10.24) and in OG for thyphoid vaccine (11.13; 7.73-16.03), Japanese encephalitis vaccine (8.54; 2.7-27.01), anthrax (25.5; 18.8-34.5), and, as expected, smallpox (71.88; 49.25-104.89). In MEDLINE, 91 articles were found: positive/possible causality was frequently reported. Conclusions: MC and PC after immunization appear extremely rare; only in very few cases can a role of vaccine be actually identified. Signals for vaccines against typhus, Japanese encephalitis, anthrax and meningococcus warrant monitoring. This case involves a 1 years old male patient who experienced viral myocarditis, while he received vaccines HAEMOPHILUS TYPE B (HIB) VACCINE, HEPATITIS A VACCINE, HEPATITIS B VACCINE, PNEUMOCOCCAL VACCINE and MMR. The patient''s past medical history included eczema and rhinitis allergic. Concomitant medication not reported. On an unknown date, the patient received a dose of suspect HAEMOPHILUS TYPE B (HIB) VACCINE produced by unknown manufacturer lot number not reported. On an unknown date, the patient received a dose of suspect HEPATITIS B VACCINE, HEPATITIS A VACCINE, MMR and PNEUMOCOCCAL VACCINE (all not produced by Sanofi Pasteur lot number not reported). On an unknown date, the patient developed a serious viral myocarditis with the symptom of pyrexia, three months following the administration of HIB VACCINE, HEPATITIS A VACCINE, PNEUMOCOCCAL VACCINE, HEPATITIS B VACCINE and MMR. The event was leading to death. Other relevant tests included normal laboratory and toxicologic tests. Final diagnosis was (fatal) viral myocarditis. It was not reported if the patient received a corrective treatment. It is unknown if an autopsy was done for this patient. Reporter assessed the causality with vaccines as undetermined. List of documents held by sender: none. Sender''s Comments: This fatal case is retrieved from a literature VAERS review and concerns a one-year-old male patient who received HEPATITIS A VACCINE, PNEUMOCOCCAL VACCINE, HEPATITIS B VACCINE, HIB VACCINE and MMR VACCINE and experienced Viral myocarditis and Pyrexia 3 months following the vaccinations. Patient''s history included Eczema and Rhinitis allergic. Time to onset is too long to be compatible with a role of the vaccines, moreover vaccination with several vaccines make the assessment of a particular vaccine difficult. Based on available information on latency and a nature of the event the role of vaccines seems unlikely. Reported Cause(s) of Death: Viral myocarditis.


VAERS ID: 776286 (history)  
Form: Version 2.0  
Age: 1.0  
Sex: Male  
Location: Oklahoma  
Vaccinated:2018-10-01
Onset:2018-10-05
   Days after vaccination:4
Submitted: 0000-00-00
Entered: 2018-10-08
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
FLU4: INFLUENZA (SEASONAL) (FLUZONE QUADRIVALENT) / SANOFI PASTEUR U1998AE / 1 RL / IM
HEPA: HEP A (VAQTA) / MERCK & CO. INC. R009953 / 1 RL / IM
MMRV: MEASLES + MUMPS + RUBELLA + VARICELLA (PROQUAD) / MERCK & CO. INC. R002938 / 1 LL / IM

Administered by: Private       Purchased by: ?
Symptoms: Autopsy, Blood lead normal, Death, Full blood count normal, Pathology test, Pyrexia, Toxicologic test
SMQs:, Neuroleptic malignant syndrome (broad), Anticholinergic syndrome (broad), Drug reaction with eosinophilia and systemic symptoms syndrome (broad)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 2018-10-05
   Days after onset: 0
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications: Zantac, Motrin, maybe Tylenol but unsure
Current Illness: 8/31/18 - diagnosed with left acute otitis media. Started Amoxil. (resolved) 9/19/18 - diagnosed with hand, foot, mouth (resolved)
Preexisting Conditions: Previously healthy
Allergies: None
Diagnostic Lab Data: All pending with medical examiner. Of note, CBC and lead screen were normal on 10/1/18 as part of his well check.
CDC Split Type:

Write-up: Received vaccines 10/1/18. Patient developed fever on of 10/3/18. Tmax 101. Mom gave Motrin before bed that night. Checked on him before she went to bed and his temp was 99. Next morning he was found dead in crib. No blankets, stuffed animals in crib. Autopsy found no signs of trauma. Tox screen, tissue samples still pending.


VAERS ID: 785626 (history)  
Form: Version 2.0  
Age:   
Sex: Female  
Location: Unknown  
Vaccinated:0000-00-00
Onset:0000-00-00
Submitted: 0000-00-00
Entered: 2018-11-13
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
DTAP: DTAP (NO BRAND NAME) / UNKNOWN MANUFACTURER - / UNK UN / UN
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. - / UNK UN / UN

Administered by: Unknown       Purchased by: ?
Symptoms: Death
SMQs:

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 0000-00-00
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications:
Current Illness: Prophylaxis
Preexisting Conditions:
Allergies:
Diagnostic Lab Data:
CDC Split Type: US0095075131811USA002457

Write-up: This spontaneous report was received from a consumer and refers to her 12-month-old daughter. The patient''s pertinent medical history, concomitant medications and drug reactions or allergies were not reported. On an unknown date, the patient was vaccinated with M-M-R II (dose, frequency, site and route of administration, lot# and expiration date were not reported) for prophylaxis. Other suspect therapies included diphtheria toxoid (+) pertussis acellular vaccine (unspecified) (+) tetanus toxoid. On an unknown date, the patient passed away due to an unknown cause. It was not reported in an autopsy was performed. The relatedness between the event and M-M-R II or diphtheria toxoid (+) pertussis acellular vaccine (unspecified) (+) tetanus toxoid was not reported.


VAERS ID: 794483 (history)  
Form: Version 2.0  
Age: 1.0  
Sex: Male  
Location: North Carolina  
Vaccinated:2017-01-30
Onset:2017-02-09
   Days after vaccination:10
Submitted: 0000-00-00
Entered: 2019-01-03
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
HEPA: HEP A (VAQTA) / MERCK & CO. INC. M039202 / 1 LG / IM
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. M016234 / 1 LG / SC
PNC13: PNEUMO (PREVNAR13) / PFIZER/WYETH R28322 / 3 LG / IM

Administered by: Private       Purchased by: ?
Symptoms: Autopsy, Blood culture negative, CSF culture negative, Computerised tomogram head normal, Culture urine negative, Death, Dyspnoea, Electroencephalogram abnormal, Encephalopathy, Endotracheal intubation, Enterovirus test negative, Fall, Febrile convulsion, Herpes simplex test negative, Hypoxia, Intensive care, Lumbar puncture normal, Muscle twitching, Myoclonus, Nuclear magnetic resonance imaging brain normal, Pharyngitis streptococcal, Polymerase chain reaction, Seizure, Stridor, Tonic clonic movements, Urine analysis normal
SMQs:, Anaphylactic reaction (broad), Agranulocytosis (broad), Angioedema (broad), Asthma/bronchospasm (broad), Neuroleptic malignant syndrome (broad), Systemic lupus erythematosus (broad), Convulsions (narrow), Dyskinesia (broad), Dystonia (broad), Oropharyngeal infections (narrow), Acute central respiratory depression (broad), Pulmonary hypertension (broad), Noninfectious encephalitis (broad), Noninfectious encephalopathy/delirium (narrow), Noninfectious meningitis (broad), Accidents and injuries (narrow), Cardiomyopathy (broad), Eosinophilic pneumonia (broad), Generalised convulsive seizures following immunisation (narrow), Chronic kidney disease (broad), Hypersensitivity (broad), Respiratory failure (broad), Drug reaction with eosinophilia and systemic symptoms syndrome (broad), Hypoglycaemia (broad), Infective pneumonia (broad)

Life Threatening? Yes
Birth Defect? No
Died? Yes
   Date died: 2018-01-04
   Days after onset: 329
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? Yes
Hospitalized? Yes, 5 days
   Extended hospital stay? No
Previous Vaccinations:
Other Medications: None
Current Illness: Patient had an adenoidectomy on January 25, 2017 in which he had recovered well from.
Preexisting Conditions: None
Allergies: None
Diagnostic Lab Data: Lumbar Puncture- Negative results; CT head- Negative; EEG-"This is an abnormal EEG. 1) There is diffuse slowing of the background with diminished organization which is more prominent in the bitemporoparietal regions. 2) Push button event at 21:13 was not clearly epileptogenic. 3) There was prominent expression of intermixed beta range frequencies diffusely throughout the record, consistent with medication effect. These findings are suggestive of focal neuronal dysfunction of the bitemporoparietal regions with an underlying mild-moderate, non-specific encephalopathy. There clear epileptiform abnormalities."; MRI Brain w/anesthesia- Negative
CDC Split Type:

Write-up: From hospital report-"12 month-old previously healthy fully immunized male presents with seizures. Patient is a twin male born at 36w6d without any complications and did not require a NICU stay. Was developing normally and has not had any recent illness, fevers or trauma. He was in the care of his nanny that has been present for approximately 3-4 weeks he began having right arm twitching which turned into a generalized seizure and he fell down and nanny caught him. He continued to have a seizure for approximately 15 minutes while he was transported to the emergency department he did receive 1.3 mg of IM VERSED. In the emergency department he had a second seizure and received 1.7 mg of VERSED and he was intubated using 3mm ETT and rocuronium. Afterwards he was loaded with KEPPRA at 30mg/kg. Head CT was negative on the way to the ICU. UA negative. UCx and BCx were collected and pt given to ROCEPHIN. In the ICU, patient was continued on a VERSED drip. He appeared stable. He did have episodes of myoclonus. vEEG was obtained. I conducted a lumbar puncture. Prior to LP, patient had an episode of myoclonus followed by tonic clonic activity for which he received aditional VERSED. Discussed the results with neurology. His myoclonus is not seizure activity however tonic clonic activity was a seizure. He continued to have a foci of activity that was central and it was recommended he receive 20mg/kg of phenobarbital." Upon admission patient was initially transferred to the PICU. Pediatric Neurology was consulted who recommended an EEG and MRI Brain. The patient was placed on continuous vEEG and initially kept on a versed drip while intubated pending completion of MRI. MRI was completed without difficulty and resulted as normal; vEEG was completed while on VERSED drip and found to be abnormal. Findings were suggestive of focal neuronal dysfunction of the bitemporoparietal regions with an underlying mild-moderate, nonspecific encephalopathy, therefore per recommendations the patient was started on maintenance KEPPRA 20mg/kg BID. Patient was without recurrent encephalopathy or return of seizures therefore was extubated later that evening on 02/10. Patient was extubated following the MRI, unfortunately he had significant stridor, increased work of breathing, and hypoxemia following extubation which did not improve after Racemic Epi, DECADRON, or High Flow Nasal Cannula therefore the patient was reintubated. He remained stable and was continued on DECADRON, he was again extubated on 02/12 without any further difficulty or respiratory distress. Infectious disease work-up continued to be reassuring including blood, urine, and CSF cultures with no growth to date as well as negative HSV and Enterovirus CSF PCR''s. Patient was transferred to the floor where he remained stable with no further seizure activity. On day of discharge, he was afebrile and hemodynamically stable on RA and tolerating PO with adequate urine output. He had no seizures further seizures, antiepileptic therapy of KEPPRA 20mg/kg BID that was initiated. Patient subsequently had another occurrence of complex febrile seizures on August 20, 2017 related to strep throat. On January 4, 2018, patient passed away in his sleep. Autopsy report- cause of death related to seizure disorder.


VAERS ID: 801757 (history)  
Form: Version 2.0  
Age:   
Sex: Unknown  
Location: Unknown  
Vaccinated:0000-00-00
Onset:0000-00-00
Submitted: 0000-00-00
Entered: 2019-02-15
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. - / 2 UN / UN

Administered by: Unknown       Purchased by: ?
Symptoms: B-lymphocyte count, Biopsy skin abnormal, CD4 lymphocytes decreased, Condition aggravated, Death, Dermatitis, Dermatitis psoriasiform, Finger amputation, Hepatitis, Immunodeficiency, Immunoglobulin therapy, Immunohistochemistry, Immunology test, Immunology test abnormal, Natural killer cell count, Polymerase chain reaction positive, Progressive multifocal leukoencephalopathy, Pyoderma gangrenosum, Rubella, Rubivirus test positive, T-lymphocyte count decreased, Vaccination complication
SMQs:, Hepatitis, non-infectious (narrow), Haematopoietic leukopenia (narrow), Malignancy related conditions (narrow), Malignancy related therapeutic and diagnostic procedures (narrow), Demyelination (narrow), Skin tumours of unspecified malignancy (broad), Hypersensitivity (narrow), Drug reaction with eosinophilia and systemic symptoms syndrome (broad), Opportunistic infections (narrow)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 0000-00-00
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications:
Current Illness: Combined immunity deficiency; Granuloma skin
Preexisting Conditions:
Allergies:
Diagnostic Lab Data:
CDC Split Type: US0095075131902USA004786

Write-up: This literature marketed report has been received from the authors of a published literature article, and refers to a 13-year-old patient of unknown gender. The patient''s concurrent condition included combined immunodeficiency CID (unknown genetics), reported as inherited immunodeficiency and cutaneous granuloma. The patient''s medical history and concomitant medications were not reported. On unknown dates at age of 5 and 9, the patient was vaccinated with M-M-R II (dose, route of administration, lot # and expiration date were not reported) for prophylaxis. On an unknown date, the patient developed immunodeficiency-related vaccine-derived rubella virus (iVDRV). The patient had skin involvement that was described as initially psoriasiform or resembling pyoderma gangrenosum. The patient had chronic inflammation in skin, liver where rubella was detected by immunofluorescence or polymerase chain reaction (PCR). The Rubella capsid was detected and the iVDRV strain with multiple non-overlapping mutations was identified in the skin biopsy by sequencing viral genomes. The patient''s CD3 count was 453 cells/uL, CD4 count 189 cells/uL, CD19 count 312 cells/uL and natural killer (NK) cell count 105 cells/uL. The authors assessed CD3 and CD4 count as low, and NK count as normal. The cutaneous granulomas spread relentlessly and led to amputation of a finger in an effort to control the spread. The surgical control of the lesion was unsuccessful. The patient was treated with linezolid, clarithromycin, rifampin, isoniazid, ethambutal, voriconazole, posaconazole, interferon and intravenous immunoglobulin (IVIG) without improvement. Nitazoxanide was used for 5 months without clinical improvement although rubella became undetectable by immunohistochemistry. The patient may have stabilized with diminished rubella capsid detection, but this patient died on an unknown date from progressive multifocal leukoencephalopathy (PML). The authors considered the iVDRV to be related to M-M-R II. Upon internal review, the iVDRV was determined to be medically significant as the patient underwent surgical amputation of finger. This is one of seven reports derived from the same literature article (linked # 1902USA004783, 1902USA004784, 1902USA004785, 1902USA003143, 1902USA004787, 1902USA004788). Sender''s Comments: US-009507513-1902USA003143.


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