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From the 5/7/2021 release of VAERS data:

Found 385 cases where Vaccine is MMR and Patient Died and Vaccination Date on/before '2015-01-31'



Case Details

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VAERS ID: 150243 (history)  
Form: Version 1.0  
Age: 1.0  
Sex: Male  
Location: Mississippi  
Vaccinated:2000-03-07
Onset:2000-03-11
   Days after vaccination:4
Submitted: 2000-03-13
   Days after onset:2
Entered: 2000-03-21
   Days after submission:8
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
DTAP: DTAP (TRIPEDIA) / CONNAUGHT LABORATORIES 7388BA / 4 - / IM
HEP: HEP B (ENGERIX-B) / SMITHKLINE BEECHAM ENG314009 / 4 - / IM
HIBV: HIB (ACTHIB) / CONNAUGHT LABORATORIES N0548AA / 3 - / IM
IPV: POLIO VIRUS, INACT. (POLIOVAX) / CONNAUGHT LTD. P0473 / 3 - / IM
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. 0928J / 1 - / SC

Administered by: Private       Purchased by: Other
Symptoms: Apnoea, Atelectasis, Brain oedema, Convulsion, Foetal disorder, Hyperplasia, Liver disorder, Petechiae, Pulmonary congestion, Pulmonary oedema, Renal disorder, Spleen disorder, Tremor
SMQs:, Cardiac failure (narrow), Hepatic failure, fibrosis and cirrhosis and other liver damage-related conditions (narrow), Haemorrhage terms (excl laboratory terms) (narrow), Neuroleptic malignant syndrome (broad), Systemic lupus erythematosus (broad), Convulsions (narrow), Parkinson-like events (broad), Acute central respiratory depression (narrow), Noninfectious encephalitis (broad), Noninfectious encephalopathy/delirium (broad), Noninfectious meningitis (broad), Hyponatraemia/SIADH (broad), Haemodynamic oedema, effusions and fluid overload (narrow), Foetal disorders (narrow), Generalised convulsive seizures following immunisation (narrow), Respiratory failure (narrow), Drug reaction with eosinophilia and systemic symptoms syndrome (broad), Hypoglycaemia (broad), Infective pneumonia (broad)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 2000-03-11
   Days after onset: 0
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications: NONE
Current Illness: NONE
Preexisting Conditions: NONE
Allergies:
Diagnostic Lab Data: Autopsy to be performed
CDC Split Type: MS00007

Write-up: No reaction or illness was noted after vaccine until the morning of 3/11/00. The child was playing and then laid down on couch and started shaking and stopped breathing. Autopsy showed cause of death to be consistent with seizure. Other findings of pulmonary vascular congestion and edema, atelectasis of the lungs, hepatic congestion, petechiae of the thymus, splenic congestion, reactive lymphoid hyperplasia of the mesenteric lymph nodes, renal congestion, fetal lobulation of the kidneys, cerebal edema.


VAERS ID: 150733 (history)  
Form: Version 1.0  
Age: 1.4  
Sex: Male  
Location: Pennsylvania  
Vaccinated:1994-07-01
Onset:1995-06-07
   Days after vaccination:341
Submitted: 2000-03-30
   Days after onset:1758
Entered: 2000-04-04
   Days after submission:4
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. - / UNK - / SC

Administered by: Other       Purchased by: Other
Symptoms: Apathy, CSF test abnormal, Coma, Confusional state, Crying, Dysarthria, Dystonia, Electroencephalogram abnormal, Encephalitis, Hyperreflexia, Myoclonus, Speech disorder, Tachycardia
SMQs:, Hyperglycaemia/new onset diabetes mellitus (broad), Neuroleptic malignant syndrome (broad), Anticholinergic syndrome (broad), Arrhythmia related investigations, signs and symptoms (broad), Dementia (broad), Dystonia (narrow), Psychosis and psychotic disorders (broad), Guillain-Barre syndrome (broad), Noninfectious encephalitis (narrow), Noninfectious encephalopathy/delirium (broad), Noninfectious meningitis (broad), Conditions associated with central nervous system haemorrhages and cerebrovascular accidents (broad), Depression (excl suicide and self injury) (broad), Drug reaction with eosinophilia and systemic symptoms syndrome (broad), Hypoglycaemia (broad), Dehydration (broad), Immune-mediated/autoimmune disorders (broad)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 0000-00-00
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications: UNK
Current Illness:
Preexisting Conditions: UNK
Allergies:
Diagnostic Lab Data: EEG-periodic high-voltage generalized sharp waves, CSF measles IgG titer-160 units, CSF measles IgG index-3.7, HIV-neg
CDC Split Type: WAES00032144

Write-up: Post vax, the pt presented with progressive confusion, crying spells, and social withdrawal. Three months after symptom onset, he developed intermittent dystonic posturing of the left arm and leg. Initial neurological exam was significant for dysarthria and myoclonus of the left arm and leg. During the fourth month of illness, the pt developed hyperreflexia, and extensor plantar responses. By the fifth month, the myoclonus ceased. He became unresponsive, mute, and displayed intermittent hyperreflexia and tachycardia suggesting autonomic dysfunction. He expired six months after the onset of symptoms. An autopsy was refused. The cause of death was subacute sclerosing panencephalitis. Information about this case is described in an unpublished manuscript entitled "Subacute sclerosing panencephalitis in US born adult".


VAERS ID: 150875 (history)  
Form: Version 1.0  
Age: 5.0  
Sex: Male  
Location: Indiana  
Vaccinated:1999-08-27
Onset:1999-09-01
   Days after vaccination:5
Submitted: 2000-03-06
   Days after onset:187
Entered: 2000-04-10
   Days after submission:34
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
DTAP: DTAP (TRIPEDIA) / CONNAUGHT LABORATORIES 0970140 / 5 LA / IM
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. 1552H / 2 RA / SC
OPV: POLIO VIRUS, ORAL (ORIMUNE) / PFIZER/WYETH 0798L / 4 MO / PO

Administered by: Public       Purchased by: Public
Symptoms: Diarrhoea, Pyrexia, Vomiting
SMQs:, Acute pancreatitis (broad), Neuroleptic malignant syndrome (broad), Anticholinergic syndrome (broad), Pseudomembranous colitis (broad), Gastrointestinal nonspecific symptoms and therapeutic procedures (narrow), Noninfectious diarrhoea (narrow), Drug reaction with eosinophilia and systemic symptoms syndrome (broad)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 1999-09-02
   Days after onset: 1
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications: Mantoux-TB
Current Illness: NONE
Preexisting Conditions: NONE
Allergies:
Diagnostic Lab Data: Autopsy report revealed the cause of death to be subacute myocardititis with heart failure.
CDC Split Type:

Write-up: September 1, 1999, woke at 2:00 AM with fever. Had diarrhea at 13:30 PM and threw up at 15:00 PM. Gave Tylenol for fever. Passed away during the night. Pronounced dead on September 2, 1999.


VAERS ID: 151082 (history)  
Form: Version 1.0  
Age: 2.0  
Sex: Female  
Location: New Hampshire  
Vaccinated:2000-03-27
Onset:2000-03-29
   Days after vaccination:2
Submitted: 2000-04-25
   Days after onset:26
Entered: 2000-04-25
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
DTAP: DTAP (INFANRIX) / SMITHKLINE BEECHAM 917A2 / UNK RL / IM
HEP: HEP B (ENGERIX-B) / SMITHKLINE BEECHAM ENG320909 / UNK LL / IM
HIBV: HIB (ACTHIB) / CONNAUGHT LABORATORIES UA497AA / UNK RL / IM
IPV: POLIO VIRUS, INACT. (NO BRAND NAME) / PASTEUR MERIEUX INST. R0398 / UNK LL / -
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. 1267J / UNK LA / SC

Administered by: Public       Purchased by: Unknown
Symptoms: Accident, Anaemia, Brain oedema, Dehydration, Gastroenteritis, Laboratory test abnormal, Pyrexia, Vomiting
SMQs:, Acute pancreatitis (broad), Haematopoietic erythropenia (broad), Hyperglycaemia/new onset diabetes mellitus (broad), Neuroleptic malignant syndrome (broad), Anticholinergic syndrome (broad), Accidents and injuries (narrow), Gastrointestinal nonspecific symptoms and therapeutic procedures (narrow), Hyponatraemia/SIADH (broad), Haemodynamic oedema, effusions and fluid overload (narrow), Noninfectious diarrhoea (broad), Drug reaction with eosinophilia and systemic symptoms syndrome (broad), Dehydration (narrow)

Life Threatening? Yes
Birth Defect? No
Died? Yes
   Date died: 2000-04-25
   Days after onset: 26
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? Yes
ER or Doctor Visit? No
Hospitalized? Yes, 20 days
   Extended hospital stay? No
Previous Vaccinations:
Other Medications: NONE
Current Illness: NONE
Preexisting Conditions: NONE
Allergies:
Diagnostic Lab Data: Venous blood lead level-elevated at 391. Autopsy revealed the pt''s cause of death as cerebral edema complicating acute lead poisoning.
CDC Split Type:

Write-up: Post vax, on 3/29/2000, child presented at ED with fever. Discharged 4/17/2000. Presented at ED with vomiting and dehydration (admission dx; Gastroenteritis) anemia. Condition deteriorated and was transferred to another medical center on 4/18/2000. Deceased on 4/21/2000.


VAERS ID: 152566 (history)  
Form: Version 1.0  
Age: 27.0  
Sex: Male  
Location: California  
Vaccinated:2000-03-30
Onset:2000-04-12
   Days after vaccination:13
Submitted: 2000-05-24
   Days after onset:42
Entered: 2000-06-01
   Days after submission:8
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. - / 1 - / SC

Administered by: Other       Purchased by: Other
Symptoms: Face oedema, Hypoxia, Lymphoma, Mouth ulceration, Pyrexia, Rash
SMQs:, Severe cutaneous adverse reactions (broad), Anaphylactic reaction (broad), Angioedema (narrow), Asthma/bronchospasm (broad), Neuroleptic malignant syndrome (broad), Systemic lupus erythematosus (broad), Anticholinergic syndrome (broad), Oropharyngeal conditions (excl neoplasms, infections and allergies) (narrow), Acute central respiratory depression (broad), Pulmonary hypertension (broad), Eosinophilic pneumonia (broad), Hypersensitivity (narrow), Malignant lymphomas (narrow), Respiratory failure (broad), Drug reaction with eosinophilia and systemic symptoms syndrome (broad), Haematological malignant tumours (narrow), Infective pneumonia (broad)

Life Threatening? Yes
Birth Defect? No
Died? Yes
   Date died: 2000-05-25
   Days after onset: 43
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? Yes
ER or Doctor Visit? No
Hospitalized? Yes, ? days
   Extended hospital stay? No
Previous Vaccinations:
Other Medications: UNK
Current Illness:
Preexisting Conditions: UNK
Allergies:
Diagnostic Lab Data:
CDC Split Type: WAES00052019

Write-up: On 4/12/00, the pt developed facial swelling on the right followed by a rash which spread over the face, neck, chest, back, and some areas of the arms and legs. The reporter noted that the pt had a fever of 104-105 but he did not have lesions in his mouth. The reporter indicated that the pt received therapy with cephalexin for treatment of the swollen cheek after the vax. At the time of the report, 5/18/00, the reporter indicated that the pt was intubated and hospitalized in an ICU. The reporter indicated that the events were life threatening. Follow-up information dated 9/26/00 stated that a bone marrow biopsy showed Natural Killer Cell Lymphoma. The pt died in the hospital on 5/25/00 after a 10 day admission. It was noted that the final cause of death was Natural Killer Cell Lymphoma.


VAERS ID: 152670 (history)  
Form: Version 1.0  
Age: 1.08  
Sex: Female  
Location: Massachusetts  
Vaccinated:2000-05-15
Onset:2000-05-25
   Days after vaccination:10
Submitted: 2000-05-30
   Days after onset:5
Entered: 2000-06-06
   Days after submission:7
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
HIBV: HIB (HIBTITER) / PFIZER/WYETH 560903A / 4 LL / IM
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. 1275J / 1 RL / SC

Administered by: Private       Purchased by: Public
Symptoms: Atelectasis, Brain oedema, Liver disorder, Pallor, Pharyngitis, Pneumonia, Pulmonary congestion, Pyrexia, Rash macular, Respiratory failure, Rhinitis
SMQs:, Cardiac failure (broad), Hepatic failure, fibrosis and cirrhosis and other liver damage-related conditions (narrow), Anaphylactic reaction (broad), Agranulocytosis (broad), Neuroleptic malignant syndrome (broad), Anticholinergic syndrome (broad), Shock-associated circulatory or cardiac conditions (excl torsade de pointes) (broad), Torsade de pointes, shock-associated conditions (broad), Hypovolaemic shock conditions (broad), Toxic-septic shock conditions (broad), Anaphylactic/anaphylactoid shock conditions (broad), Hypoglycaemic and neurogenic shock conditions (broad), Oropharyngeal infections (narrow), Acute central respiratory depression (narrow), Guillain-Barre syndrome (broad), Hyponatraemia/SIADH (broad), Haemodynamic oedema, effusions and fluid overload (narrow), Eosinophilic pneumonia (broad), Hypotonic-hyporesponsive episode (broad), Hypersensitivity (narrow), Respiratory failure (narrow), Drug reaction with eosinophilia and systemic symptoms syndrome (broad), Infective pneumonia (narrow), Hypokalaemia (broad)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 2000-05-28
   Days after onset: 3
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications: PPD - Lot number 0090P, ID, RA
Current Illness: NONE
Preexisting Conditions: febrile seizures, pneumococcal bacteremia
Allergies:
Diagnostic Lab Data: CBC-5500
CDC Split Type:

Write-up: on 5/25/00, pt had fever, cold symptoms for 2 days, runny nose, red pharynx, a few papules on face, WBC 5,500. 5/27 via phone call, pt was pale, had macular rash on nose and face, fever was 100.8. Pt was taken to ER on 5/28. DOA, (probably several hours). Autopsy states liver congestion, lung atelectasis, lung congestion, respiratory failure due to streptococcal (group B) pneumonia, ceberal edema,


VAERS ID: 155775 (history)  
Form: Version 1.0  
Age: 1.25  
Sex: Male  
Location: New Mexico  
Vaccinated:2000-06-09
Onset:2000-06-17
   Days after vaccination:8
Submitted: 2000-06-20
   Days after onset:3
Entered: 2000-06-29
   Days after submission:9
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
DTAP: DTAP (TRIPEDIA) / CONNAUGHT LABORATORIES U0173CA / 4 LL / IM
HIBV: HIB (ACTHIB) / CONNAUGHT LABORATORIES UA481AA / 4 RL / IM
IPV: POLIO VIRUS, INACT. (NO BRAND NAME) / PASTEUR MERIEUX INST. R06172 / 4 RL / SC
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. 1268J / 1 RL / SC

Administered by: Private       Purchased by: Public
Symptoms: Respiratory arrest
SMQs:, Anaphylactic reaction (broad), Acute central respiratory depression (narrow), Guillain-Barre syndrome (broad), Hypersensitivity (broad), Respiratory failure (narrow)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 2000-06-19
   Days after onset: 2
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications:
Current Illness: Allergic rhinitis, eczema
Preexisting Conditions: 4 1/2 weeks premature
Allergies:
Diagnostic Lab Data: Body sent for autopsy
CDC Split Type:

Write-up: Sudden onset of respiratory arrest and subsequent brain death. 07/27/2000 final autopsy report not get typed but findings are:Aucal herniation 2 degree to: 1. diffuse cerbral edema 2 degree 2. Severe micro vesicular for steotosis metabolic enephalopathy. Reye''s Syndrome still susoected but apparently injection of ASA has not been verified. MD still considered it a toxic event. Typed report should be available in about 1 week.


VAERS ID: 163135 (history)  
Form: Version 1.0  
Age: 1.3  
Sex: Female  
Location: Tennessee  
Vaccinated:2000-09-05
Onset:2000-09-06
   Days after vaccination:1
Submitted: 2000-11-05
   Days after onset:60
Entered: 2000-12-06
   Days after submission:31
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
DTAP: DTAP (INFANRIX) / SMITHKLINE BEECHAM 941A2 / 3 LA / IM
HEP: HEP B (ENGERIX-B) / SMITHKLINE BEECHAM 3142A2 / 2 LA / IM
HIBV: HIB (ACTHIB) / CONNAUGHT LABORATORIES UA524AA / 3 RA / IM
IPV: POLIO VIRUS, INACT. (POLIOVAX) / CONNAUGHT LTD. R06913 / 2 LA / SC
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. 0539J / 1 RL / SC

Administered by: Public       Purchased by: Public
Symptoms: Asphyxia, Unevaluable event
SMQs:, Acute central respiratory depression (broad), Hostility/aggression (broad), Respiratory failure (broad)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 2000-09-06
   Days after onset: 0
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications:
Current Illness:
Preexisting Conditions:
Allergies:
Diagnostic Lab Data: NONE
CDC Split Type:

Write-up: Infant was behind on immunizations. Mother gave a negative history for previous adverse reactions. Infant was put to bed for the evening and expired. Cause of death is undetermined. Autopsy states cause of death as asphyxia.


VAERS ID: 164713 (history)  
Form: Version 1.0  
Age: 1.25  
Sex: Female  
Location: Massachusetts  
Vaccinated:2001-01-05
Onset:2001-01-06
   Days after vaccination:1
Submitted: 2001-01-08
   Days after onset:2
Entered: 2001-01-16
   Days after submission:8
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
DTAP: DTAP (TRIPEDIA) / CONNAUGHT LABORATORIES U0313AA / UNK RL / IM
HIBV: HIB (HIBTITER) / PFIZER/WYETH 471876 / UNK RL / IM
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. 1327J / UNK LL / SC
PNC: PNEUMO (PREVNAR) / PFIZER/WYETH 473341 / UNK RL / IM
VARCEL: VARICELLA (VARIVAX) / MERCK & CO. INC. 1869J / UNK LL / SC

Administered by: Private       Purchased by: Unknown
Symptoms: Unevaluable event
SMQs:

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 2001-01-06
   Days after onset: 0
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications: Poliovax by Connaught, Lot #R0692 given SC
Current Illness: Constipation
Preexisting Conditions: Cerebral dysgenesis, congenital CMV, developmental delay
Allergies:
Diagnostic Lab Data:
CDC Split Type:

Write-up: On 1/8/01, the physician received a phone call stating that the pt died on 1/6/01 in the A.M.


VAERS ID: 164955 (history)  
Form: Version 1.0  
Age: 20.0  
Sex: Male  
Location: Unknown  
Vaccinated:0000-00-00
Onset:1990-02-01
Submitted: 2001-01-15
   Days after onset:4001
Entered: 2001-01-22
   Days after submission:7
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. - / 2 - / SC

Administered by: Unknown       Purchased by: Unknown
Symptoms: Coma, Convulsion, Drug ineffective, Dysarthria, Electroencephalogram abnormal, Encephalitis, HIV infection, Haemoglobin decreased, Leukopenia, Lymphopenia, Muscle twitching, Necrosis, Nervous system disorder, Respiratory distress, Tachypnoea, Thrombocytopenia
SMQs:, Anaphylactic reaction (broad), Asthma/bronchospasm (broad), Haematopoietic erythropenia (broad), Haematopoietic leukopenia (narrow), Haematopoietic thrombocytopenia (narrow), Lack of efficacy/effect (narrow), Haemorrhage laboratory terms (broad), Hyperglycaemia/new onset diabetes mellitus (broad), Neuroleptic malignant syndrome (broad), Systemic lupus erythematosus (narrow), Convulsions (narrow), Dyskinesia (broad), Dystonia (broad), Acute central respiratory depression (broad), Guillain-Barre syndrome (broad), Noninfectious encephalitis (narrow), Noninfectious encephalopathy/delirium (broad), Noninfectious meningitis (broad), Eosinophilic pneumonia (broad), Conditions associated with central nervous system haemorrhages and cerebrovascular accidents (broad), Generalised convulsive seizures following immunisation (narrow), Hypersensitivity (broad), Respiratory failure (narrow), Drug reaction with eosinophilia and systemic symptoms syndrome (broad), Hypoglycaemia (broad), Infective pneumonia (broad), Immune-mediated/autoimmune disorders (broad)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 0000-00-00
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? Yes, ? days
   Extended hospital stay? No
Previous Vaccinations:
Other Medications: hemophilia A, HIV
Current Illness:
Preexisting Conditions: Hemophilia A; human immunodeficiency virus infection
Allergies:
Diagnostic Lab Data: CSF and CT of head-were nml; EEG-showed right frontal slowing with spike discharges centrally; CBC-nml; CXR-nml; lab-showed evidence of the syndrome of inappropriate secretion of adrenocorticotropic hormone was found; Titers of measles antibody at this time were undetectable; autopsy-the brain weighed 1.540 g (expected weight, 1.350 g) and its gross characteristics were nml; Focal acute neuronal necrosis was evident in the dentate nucleus
CDC Split Type: WAES01010267

Write-up: In 4/90, 11 days post vax, the pt experienced recurrent focal seizures. At the time his HIV infection was diagnosed in 10/85, blood analysis consistently revealed leukopenia, mild thrombocytopenia and hemoglobin concentrations of 11.2 to 13.6, lymphocyte counts were around 200-300, CD4 to CD8 ratios of 0.2-0.47. In 10/89, therapy with zidovudine was initiated. The pt had no symptoms related to HIV infection or zidovudine therapy. Although he had received the measles vaccine in 1973 at the age of 3 and a dose of MMR in 1976 at the age of 7, the pt was admitted to the hospital for three days in 2/90 with uncomplicated measles. Tachypnea and respiratory distress responded promptly to therapy with oxygen and aerosolized ribavirin. The pt responded well until two months later, when he presented after two days of recurrent right arm twitches without fever. Physical exam revealed only continuous fine twitches of th right arm. CSF analysis and computed tomography of the head gave normal results, electroencephalography, however, showed right frontal slowing with spike discharges centrally, persisted despite therapeutic anticonvulsant concentrations in serum. the pt was admitted 11 days after the onset of seizures for further diagnostic evaluation. At the time of admission, he was conscious and afebrile. He had right-arm and right-leg twitching but was able to walk. His mental status and the results of motor and sensory examination were normal. Although the latter condition responded to the fluid restriction, the pt developed slurred speech and gradually became unresponsive requiring endotracheal intubation. A 10 day course of IV therapy was given. The pt remained comatose, experiencing continuous focal seizures that could not be controlled with anticonvulsant agents. Neurological and electroencepahlographic exam on day 24 of hospitalization indicated brain death. Mechanical ventilation was discontinued on day 30. The cause of death was subacute measles encephalitis.


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