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This is VAERS ID 582177

Case Details

VAERS ID: 582177 (history)  
Form: Version 1.0  
Age:   
Sex: Female  
Location: Foreign  
Vaccinated:0000-00-00
Onset:0000-00-00
Submitted: 2015-06-15
Entered: 2015-06-16
   Days after submission:1
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
HPV2: HPV (CERVARIX) / GLAXOSMITHKLINE BIOLOGICALS - / UNK UN / UN

Administered by: Other       Purchased by: Other
Symptoms: Arthralgia, Autoantibody positive, Blood test normal, CSF protein increased, Electromyogram abnormal, Gait inability, Malaise, Nerve conduction studies normal, Nuclear magnetic resonance imaging brain normal, Nuclear magnetic resonance imaging spinal normal, Pain, Pyrexia
SMQs:, Rhabdomyolysis/myopathy (broad), Peripheral neuropathy (broad), Neuroleptic malignant syndrome (broad), Anticholinergic syndrome (broad), Dystonia (broad), Guillain-Barre syndrome (broad), Arthritis (broad), Drug reaction with eosinophilia and systemic symptoms syndrome (broad), Immune-mediated/autoimmune disorders (broad)

Life Threatening? No
Birth Defect? No
Died? No
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications: No other medications
Current Illness: Unknown
Preexisting Conditions:
Allergies:
Diagnostic Lab Data: Unknown date: Nerve conduction study and head and spinal contrast enhanced magnetic resonance imaging (MRI): No abnormalities were noted. Unknown date: Needle electromyography: Neurogenic changes with reinnervation were noted predominantly in the proximal muscle. Unknown date: Blood test: Inflammatory reactions did not increase. Protein in cerebrospinal fluid increased. Anti-glutamate receptor (GluR) antibody was detected in both serum and cerebrospinal fluid.
CDC Split Type: JP2015JPN078249

Write-up: This case was reported in a literature article and described the occurrence of abasia in a 19-year-old female patient who received CERVARIX. On an unknown date, the patient received CERVARIX at an unknown dose. On an unknown date, the patient received CERVARIX at an unknown dose. On an unknown date, unknown after receiving CERVARIX, the patient experienced abasia (serious criteria GSK medically significant), arthralgia, slight fever, general malaise and pain. On an unknown date, the outcome of the abasia was recovering/resolving and the outcome of the arthralgia, slight fever, general malaise and pain were unknown. It was not reported if the reporter considered the abasia, arthralgia, slight fever, general malaise and pain to be related to CERVARIX. The subject was a 19-year-old woman. She was vaccinated with CERVARIX at the age of 18 years, and had arthralgia, slight fever, and general malaise on the day of the vaccination. Pain persisted with fluctuating. After the second vaccination, the subject had arthralgia all over the body, and abasia developed due to marked pain. No laboratory findings indicated autonomic nerve disorder. Nerve conduction study showed no abnormalities, but needle electromyography showed neurogenic changes with reinnervation predominantly in the proximal muscle. Head and spinal magnetic resonance imaging (MRI) showed no abnormalities. Blood test did not show increased inflammatory reactions. Protein in cerebrospinal fluid increased. Since anti-glutamate receptor (GluR) antibody was detected in both serum and cerebrospinal fluid, an immunological mechanism was presumed. Thus 1 course of steroid pulse therapy was performed, and then 3 courses of steroid pulse therapy was performed, and then 3 courses of immunoadsorption therapy with a tryptophan column as a secondary column were performed. After the treatment, pain decreased approximately by half and the subject became able to walk a short distance.


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