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Life Threatening? No
Write-up: This literature market report has been received from the author of the published literature article. The objective of this communication was to describe 2 previously healthy girls who developed a chronic incapacitating fibromyalgia-like illness after HPV vaccination. Case 2. A healthy 14-year-old girl developed severe neck pain 4 weeks after her second GARDASIL shot. For the ensuing weeks, pain spread to her arms and then to her legs. She developed paresthesias in the 4 extremities. Because of her symptoms, she could not sleep well or attend school. She lived in a harmonic household, and there was no personal history of trauma, anxiety, or depression. She has a family history of spondyloarthropathy. Physical examination showed an uncomfortable-looking girl crying in pain. She had exquisite tenderness at palpations all over her body including all 18 fibromyalgia tender point sites. The remainder of the physical examination was normal. There was no arthritis or enthesopathy. Extensive diagnostic workup was negative. No infectious, inflammatory, or autoimmune illness could be detected. HLAB27 was negative. Several analgesic, corticosteroid, or antineuropathic medication provided only transient mild relief. Five months after the onset of her illness, she still had widespread pain and paresthesias. The author discussed that in case 2, vaccination-pain relationship is less clear; her intriguing illness developed 4 weeks after her second vaccine injection. In both instances, multiple specialist consultations and diagnostic procedures found no other plausible explanation for a severe persistent fibromyalgia-like illness developing at their young age. The author suggested that the medical community and regulatory agencies be aware of these possible adverse effects in order to define their real magnitude, and if indicated, to take corrective actions. The event was considered as disability because the patient could not attend to school. This is one of several reports received from the same literature. Additional information has been requested.
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