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Life Threatening? No
Write-up: This case was reported by a consumer and described the occurrence of addisonian crisis in a 18-year-old female subject who was vaccinated with CERVARIX, GlaxoSmithKline. A physician or other health care professional has not verified this report. Concurrent medical conditions included congenital adrenal hyperplasia. Concurrent medications included Hydrocortisone, Fludrocortisone and Hydrocortisone. On 4 September 2009 the subject received dose of CERVARIX (injection, intramuscular). On 4 September 2009, within hours of vaccination with CERVARIX, the subject experienced nausea, dizziness, sensory loss, condition aggravated. The subject was hospitalized. On 07 September 2009, approximately 3 days after vaccination, the subject was diagnosed with addisonian crisis. Feeling unwell and low cortisol. At the time of reporting nausea, dizziness, sensory loss and condition aggravated were improved. Feeling unwell was unresolved and outcome for addisonian crisis and low cortisol were unknown. Verbatim text: A consumer reported on 11/11/2009 that 18 year old daughter received first dose of CERVARIX vaccine on 04/09/2009. The doctor was aware that her daughter had a pre-existing medical condition "Congenital adrenal hyperplasia (also known as Addison''s disease ) and had made a clinical decision to proceed with CERVARIX vaccination. Within a few hours after the first CERVARIX vaccination, her medical condition worsened whereby her daughter had "terrible nausea, extreme dizziness and loss of sense down left hand side of body''. Her symptoms had not improved and therefore on 07/09/2009, the patient was admitted to hospital which who was diagnosed for Addison''s crisis'' which normally arose from an infection. However on infection was diagnosed in this instance. Her daughter was discharged on 11/09/2009 but still felt unwell. Subsequently on 15/10/2009, her daughter was admitted to hospital for second ''Addison''s crisis'' with no diagnosed infection. Her daughter was discharged on 22/10/2009. On 04/11/2009, at an outpatients clinic visit, her daughter''s blood levels revealed low cortisol levels, although she was taking long term hydrocortisone 20mg day and Fludrocortisone 200mcg daily. Up till the time of reporting, her daughter''s condition had improved but still felt unwell. Another blood test was completed on 10/11/2009 and awaiting further results. No batch details of further information was available at the time of reporting.
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