Your Health. Your Family. Your Choice.
Administered by: Unknown Purchased by: Unknown
Life Threatening? No
Write-up: Case received from foreign Health Authority on 23-MAR-2009 under HA reference no. PEI2009004813. It was reported by a physician that 17 year old female patient with a positive family anamnesis of multiple sclerosis (aunt of the patient, currently without symptoms) and medical history of preexisting left-frontal headache and left-temporal brain substance defect (probably due to an craniocerebral injury in childhood) was vaccinated with three doses of GARDASIL (Lot # not reported) in 2007 (exact dates not reported). On 08-FEB-2007 the patient was vaccinated with Tdap (manufacturer unknown), on 22-MAR-2007 with a dose of HBVAXPRO (Lot # not reported) and 18-APR-2007 with a dose of TWINRIX, Lot # not reported) and finally on 31-MAY-2007 with HAVRIX (lot # not reported). Between 15-JAN-2009 and 20-JAN-2009 she experienced visual disturbance which led to diagnosis of suspicion of clinical isolated syndrome. On 09-FEB-2009 she experienced hemilateral weakness for seconds or minutes without nausea and headache. Neurological examination and psychic exploration were normal. Findings: Cranial MRI showed several lesions centrally located in the medulla oblongata without enhancement of contrast medium. MRA on 11-FEB-2009, MRI of cervical and thoracic spine, VEF, EEG on 16-FEB-2009, tibial sep. Neurological and psychological investigations showed normal results. Routine laboratory findings were normal. CSF diagnosis: 390/3-cells (<15), total protein: 49mg/dl, lactate: 14mg/dl, detection of intrathecal IgG synthesis and oligloclonal bands, slight barrier disorder, albumin quotient: 4.2, varicella zoster IgG (CSF): 27IU/l (<4.5), ASI: 2.01 (no confirmation of intrathecal antibody synthesis). Infection serology (borrelia, varicella zoster, CMV, toxoplasmosis, mumps, measles, influenza A and B, HSV, FSME, EBV and rubella) detected no acute infection. ACE and ANA were normal. Brain stem encephalitis was diagnosed. It was discussed whether brain stem encephalitis was within a CIS or ADEM. MRI was not in favor of ADEM but could be se
Copyright © 2018 National Vaccine Information Center. All rights reserved.
21525 Ridgetop Circle, Suite 100, Sterling, VA 20166