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This is VAERS ID 339718

Case Details

VAERS ID: 339718 (history)  
Age: 13.0  
Gender: Female  
Location: Indiana  
Vaccinated:2008-11-03
Onset:2008-11-29
   Days after vaccination:26
Submitted: 2009-02-17
   Days after onset:80
Entered: 2009-02-17
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
HPV4: HPV (GARDASIL) / MERCK & CO. INC. 0548X / 0 RA / IM
TDAP: TDAP (ADACEL) / SANOFI PASTEUR C2927AA / 0 UN / IM

Administered by: Unknown       Purchased by: Unknown
Symptoms: Abasia, Aphasia, Asthenia, Computerised tomogram, Convulsion, Echocardiogram, Electrocardiogram, Electroencephalogram, Encephalitis, Gait disturbance, Gastrointestinal tube insertion, Lumbar puncture, Mechanical ventilation, Nuclear magnetic resonance imaging, Unresponsive to stimuli
SMQs:, Peripheral neuropathy (broad), Hyperglycaemia/new onset diabetes mellitus (broad), Neuroleptic malignant syndrome (broad), Systemic lupus erythematosus (broad), Anticholinergic syndrome (broad), Dementia (broad), Convulsions (narrow), Dystonia (broad), Parkinson-like events (broad), Acute central respiratory depression (broad), Guillain-Barre syndrome (broad), Noninfectious encephalitis (narrow), Noninfectious encephalopathy/delirium (broad), Noninfectious meningitis (broad), Conditions associated with central nervous system haemorrhages and cerebrovascular accidents (broad), Hypotonic-hyporesponsive episode (broad), Generalised convulsive seizures following immunisation (narrow), Respiratory failure (broad), Drug reaction with eosinophilia and systemic symptoms syndrome (broad), Hypoglycaemia (broad)

Life Threatening? Yes
Died? No
Permanent Disability? Yes
Recovered? No
ER or Doctor Visit? Yes
Hospitalized? Yes, 79 days
   Extended hospital stay? Yes
Previous Vaccinations: Encephalitis~HPV (Gardasil)~1~13.60~Patient
Other Medications: N/A
Current Illness: None
Preexisting Conditions: None PMH: Family hx: epilepsy
Diagnostic Lab Data: MRI,Spinal Tap,CT scan, EEG, Echo gram, EKG and multiple other tests. She has been hospitalized. LABS: CBC & CMP WNL. ESR 63(H). CT & MRI head WNL. EEG abnormal. CSF: WBC 84(H), lymphs 94%(H), protein & CSF WNL.
CDC Split Type:

Write-up: Approx 3 weeks after getting 1st set of Gardasil, patient complained that she was weak and was having a hard time speaking. On 11/29/08 patient had 2 seizures. She was was taken to the ER. Since the first few days of her illness, she stopped being able to talk, walk and has been completely unresponsive. She is on a ventilator & has a feeding tube. She has neurological movements. All of the testing done shows that patient has encephalitis. The cause of the Encephalitis is a reaction to the Gardasil Vaccine. 2/18/09 Received hospital medical records of 12/1-12/4/2008. FINAL DX: meningoencephalitis w/significant mental changes & seizures Records reveal patient experienced seizure that progressed to loss of speech, sustained focal seizures, oral intake reduced, drowsiness, floppy. Developed fever in hospital. Neuro & ID consult done. Tx w/antiseizure meds, antivirals, antibiotics. Transferred to higher level of care peds neuro ICU. 3/9/09 Received ER records of 12/5/08. FINAL DX: Encephalitis/encephalopathy; seizure disorder; history of depression w/suicidal attempts Records reveal patient had been transferred from outlying hospital. Exam revealed drowsiness, not able to follow commands, PERRL, hypertonicity of all limbs, DTRs increased. No PICU bed available & held in ER. Neuro consult done. Tx w/antivirals & continued on antiseizure meds. 3/9/09 Received hospital medical records of 2/10-currently inpatient FINAL DX: recent viral encephalitis(presumed HSV) & subsequent neurologic devastation presented w/MSSA septic shock, DIC, acute on chronic respiratory failure, acute renal failure, s/p tracheostomy Records reveal patient had been d/c from PICU w/HSV encephalitis 10/2008 w/resulting severe neurological damage. Now w/fever, hypotension & decreased mental status. Transferred from outlying ER w/platelets of 17. Tx w/IV antibiotics, plts/FFP/PRBC transfusions, pressors. Patient trach to vent w/large amount yellow sputum.


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