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This is VAERS ID 332160

Case Details

VAERS ID: 332160 (history)  
Age: 13.0  
Gender: Female  
Location: California  
Vaccinated:2007-03-05
Onset:2007-03-20
   Days after vaccination:15
Submitted: 2008-11-05
   Days after onset:596
Entered: 2008-11-12
   Days after submission:7
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
HPV4: HPV (GARDASIL) / MERCK & CO. INC. 0961F / 0 UN / UN

Administered by: Private       Purchased by: Other
Symptoms: Back pain, Blood immunoglobulin G increased, Chest X-ray, Hypoaesthesia, Neuromyelitis optica, Nuclear magnetic resonance imaging abnormal, Nuclear magnetic resonance imaging brain abnormal, Nuclear magnetic resonance imaging thoracic abnormal, Optic neuropathy, Pain in extremity, Rash, Spinal disorder
SMQs:, Anaphylactic reaction (broad), Peripheral neuropathy (broad), Retroperitoneal fibrosis (broad), Guillain-Barre syndrome (broad), Optic nerve disorders (narrow), Cardiomyopathy (broad), Demyelination (narrow), Hypersensitivity (narrow), Tendinopathies and ligament disorders (broad), Drug reaction with eosinophilia and systemic symptoms syndrome (broad)

Life Threatening? Yes
Died? No
Permanent Disability? Yes
Recovered? No
ER or Doctor Visit? Yes
Hospitalized? Yes, 2 days
   Extended hospital stay? No
Previous Vaccinations:
Other Medications:
Current Illness: none
Preexisting Conditions: none 11/24/08-records received-PMH: constipation. Raynaud's phenomenon. Eczema.
Diagnostic Lab Data: 1/15/07, upper GI; 2/28/08, MRI Brain scan to determine damage to optic nerve; 4/10/08, MRI thoracic spine, lesion discovered; 4/14/08, chest x ray; 6/18/08, MRI thoracic spinal lesion confirmed; 7/14/08, MRI thoracic (follow up); 8/20/08, MRI thoracic lesion noted 11/24/08-records received-MRI cervical spine, thoracic spine showed increased T2 hyperintensity from T2 through T10 with enhancement from T6-Y10, large enhancing lesion in thoracic spine. NMO antibody positive.
CDC Split Type:

Write-up: 12/06-1/12/07 abdominal pain, nausea, vomiting. 1/15/07 upper GI. 3/15/07 GARDASIL #1. 3/20/07 unknown rash. 5/7/07 GARDASIL #2. 5/26/07 unknown rash. 9/14/07 GARDASIL #3. 9/24/07 unknown rash. 11/27/07 unknown rash. 2/20/08 ATTACK...left optic neuropathy, treated with prednisone over several days. Test positive for NMO IgG. 2/28/08 MRI Brain scan to determine damage to optic nerve. 3/1/08-5/18/08 prednisone treatment plan. 3/27/08 diagnosis of NMO from clinic. Discussed treatment with RITIXIMAB. 4/10/08 MRI thoracic spine, lesion discovered. 4/14/08 chest x ray. 5/16/08 leg pain, numbness. 5/20/08 hospital visit confirm diagnosis of NMO. 6/15/08-6/17/08 ATTACK...back pain/numbness in right leg/stomach numbness. 6/18/08 MRI thoracic spinal lesion confirmed. 6/18-6/22 Infusion SOLU-MEDROL 1000 mg (home). 6/22/08 ATTACK..back pain/numbness right leg/stomach numbness. 6/23/08-8/9/08 MEDROL tablet started. 7/14/08 MRI thoracic (follow up). 7/16 Infusion SOLU-MEDROL 1000 mg (hospital). 7/30/08 Infusion SOLU-MEDROL 1000 mg (hospital). 8/20/08 back pain. 8/20/08 MRI thoracic lesion noted. 10/3/08 back pain. 10/6/08 ATTACK...back pain. 10/7/08 back pain. 10/7/08-10/11/08 Infusion SOLU-MEDROL 1000mg (hospital). 10/27/08 mild back pain. 10/27/08 Infusion SOLU-MEDROL 1000mg (home). The medical team''s initial evaluation, at this time, leads them to believe than the GARDASIL vaccine was the "trigger" that caused the NMO to surface. 11/24/08-records received-Neurology consult 6/20/08-3-5 episodes nausea and vomiting December 2006, symptoms resolved. Rashes after 3 Gardasil vaccinations. In February while on vacation in Mexico developed pain and decreased vision in left eye. MRI demonstrated enhancing lesion in left optic nerve, neuraxis. DX neuromyelitis optica. Three weeks ago intermittent episodes low back pain and hospitalized for severe impaction. Now C/O recurrence of back pain and numbness below waist. C/O numbness in both lower extremities left greater than right. 1/28/2010 Diagnosed with Neuromyelitis Optica (NMO) and continues to have attacks which leave spinal lesions in place. On combination of drugs to mitigate attacks.


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