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Life Threatening? No
Write-up: This case was reported by a physician and described the occurrence of intussusception of intestine in a 4-month-old female subject who was vaccinated with ROTARIX (GlaxoSmithKline). Previous and/or concurrent vaccination included DTPa-IPV-HIB; manufacturer unspecified; intramuscular given on 25 February 2008; hepatitis B vaccine recombinant; manufacturer unspecified; intramuscular given on 8 December 2007 and 25 February 2008; pneumococcal vaccine, unspecified (manufacturer unspecified; intramuscular given on 25 February 2008; tuberculosis vaccine; non-GSK manufacturer; intradermal given on 3 December 2007. On 5 February 2008 the subject received 1st dose of ROTARIX (oral). On 03 April 2008, 2 months after vaccination with ROTARIX, the subject was in the emergency room due to 1 day of evolution of gastric vomiting (8 times), intolerance to oral intake and 2 bloody stools (seemed like black current jelly stools). Relevant test include abdominal x-ray finding air-fluid levels and data of intestinal obstruction. The same day the subject underwent a surgery in which it was found ileococecal intussusception with necrosis ileum (8 cm) and ascending colon (15 cm). A prophylactic appendectomy was also done and termini terminal union without complications. On 10 April 2008, 7 days after the subject presented a good evolution, therefore he was discharged. The subject was treated with cefotaxime, amikacin and metronidazole. The subject was hospitalised and the physician considered the events were clinically significant (or requiring intervention). On 10 April 2008, the events were resolved. The physician considered the events were possibly related to vaccination with ROTARIX. On 25 April 2008 the subject was revaccinated with the 2nd dose of ROTARIX (oral), 2nd dose of DTPa-IPV-HIB; manufacturer unspecified; intramuscular and 2nd dose of pneumococcal vaccine, unspecified; manufacturer unspecified.
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