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Life Threatening? No
Write-up: This case was reported by a physician and described the occurrence of invagination of intestine in a 3-month-old female subject who was vaccinated with ROTARIX (GlaxoSmithKline). The subject had no history of family history of intussusception or bowel abnormalities. She had no congenital intestinal malformation or other gastrointestinal malformation and dysfunction. Previous and/or concurrent vaccination included DTaP-IPV-HIB (manufacturer unspecified; intramuscular) given on 18 January 2008; hepatitis B vaccine recombinant (manufacturer unspecified; intramuscular) given on 4 November 2007 and 18 January 2008; pneumococcal vaccine, unspecified (manufacturer unspecified; intramuscular) given on 18 January 2008; tuberculosis vaccine (manufacturer unspecified; intradermal) given on 4 November 2007. On 18 January 2008, the subject received the 1st dose of ROTARIX (oral, lot number not provided). On 21 January 2008, 3 days after vaccination with the 1st dose of ROTARIX, the subject experienced invagination of intestine. The subject started with alimentary vomiting and intolerance to PO with 30 hrs of evolution, she was treated with co-trimoxazole and metoclopramide. On 23 January 2008 at 13.00 hrs, the subject had diagnosis of moderate dehydration and was giving oral hydration. She came back for another consult on the same day at 15.35 hrs with stools that "seemed like black currant jelly"; hospitalization was required with the diagnosis of intestinal intussusception. Abdominal radiograph, abdominal ultrasound and abdominal CT were not performed. The physician considered the events were clinically significant (or requiring intervention). A close reduction surgery was performed on 23 January 2008 without complications by laparotomy finding ileo ileal and ileo colic invagination with data of intestinal ischemia that began to remit at the end of procedure. Intestinal resection was not required. On 23 January 2008, intestinal invagination resolved. The physician considered the events were possibly related to vaccination with ROTARIX. Physician didn''t have a favorable progress note or a surgery note after this data. No more information available.
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