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Life Threatening? Yes
Write-up: This case was reported by a physician in the frame of a PASS study and described the occurrence of intussusception in a 7-month-old female subject who was vaccinated with ROTARIX (GlaxoSmithKline). Previously, the subject was healthy. Previous vaccination included ROTARIX (GlaxoSmithKline; oral) given on 6 December 2007. On 5 February 2008, the subject received the 2nd dose of ROTARIX (oral). On 12 March 2008, 36 days after vaccination with the 2nd dose of ROTARIX, the subject experienced oral intolerance, gastroalimentary vomiting, then biliar and one liquid stool. The subject was hospitalised on ER (date of hospitalisation was not available in the chart). The subject showed 11 "mucosanguinolent" stools, malaise, pallor, abdominal distension, dehydration and most severe conditions. Laboratory tests were performed and showed the following: Hemoglobin: 10.9 g/dL (normal range: 10.0-13.0); Hematocrit: 32.7 % (normal range: 29-42); Platelets count: 489000/mm3 (normal range: 300000-700000); Neutrophils: 75.5% (normal range: 13-33); Sodium 143 mEq/L (normal range: 135-145); Potassium: 4.3 mEq/L (normal range: 3.7-5.5). Entamoeba histolytica test (fresh stool) was performed and was negative. The subject was sent to another hospital with surgical pediatric attention. On 15 March 2008, at physical exam, the subject showed severe dehydration, pallor, malaise, tonic-clonic generalized convulsions, neurological deterioration, abdominal zone with distension, pain, without palpable mass, expulsion of current jelly stool and delayed capillary filling. No abdominal x-ray was reported in the clinical file. On 15 March 2008, laboratory tests were performed and showed the following: Hemoglobin: 6 g/dL (normal range: 10.0-13.0); Potassium: 2.1 mEq/L (normal range: 3.5-5.5). On 15 March 2008, the subject received the first transfusion of globular package (86ml) without complication. On 15 March 2008, surgery was performed; intussusception ileo-ceco-colic was found with large invagination up to descendent colon with ischemic intestin
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