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Life Threatening? No
Write-up: This case was reported by a physician and described the occurrence of invagination of intestine in a 4-month-old female subject who was vaccinated with Rotarix (GlaxoSmithKline). The subject had no family history of intussusception or bowel abnormalities. The subject had no history of the following: previous intra-abdominal surgery, congenital intestinal malformation, intestinal polyps, Meckels diverticulum, intestinal vascular malformations, cystic fibrosis, Hirschsprung disease, other gastrointestinal malformation and dysfunction or intussusception. Previous and/or concurrent vaccination included DTap-IPV-HIB (manufacturer unspecified; intramuscular; unknown) given on 15 February 2008; Hep B (manufacturer unspecified; intramuscular; unknown) given on 15 November 2007 and 15 January 2008; pneumococcal vaccine, unspecified (manufacturer unspecified; intramuscular; unknown) given on 15 February 2008; tuberculosis vaccine (GlaxoSmithKline; intradermal; unknown) given on 15 November 2007. On 18 March 2008 and 15 January 2008, the subject received the 2nd dose and the 1st dose of Rotarix (oral). On unspecified date (one week before admission), at an unspecified time after vaccination with Rotarix, the subject started with hyaline rhinorrhea and fever with good response after receiving non specific treatment. However on 05 April 2008 she presented generalized seizures, reason why she was admitted to hospital, at the same time she started with bloody stools. The subject was hospitalised and the physician considered the events were clinically significant (or requiring intervention). Physical examination reported dehydration, irritability, pharyngotonsillitis with hyperemia, purulent exudates without no respiratory difficulty or meningeal irritation, non-tender abdomen, normal peristalsis, only rectal bleeding was observed and gastrobiliary vomiting. On left abdomen a pain-palpable mass (Morcilla and Dance signs) was found. Abdominal X-ray was performed and showed bad distribution of air and distal absence. Pl
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