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Life Threatening? No
Write-up: This case was reported by a physician in the frame of a study and described the occurrence of intussusception in a 9-month-old male subject who was vaccinated with ROTARIX (GlaxoSmithKline). The subject was under no other medication and had no relevant medical history nor allergy. Previous and/or concurrent vaccination included attenuated human rotavirus vaccine ;GlaxoSmithKline ;oral given on 11 July 2007. On 11 September 2007, the subject received 2nd dose of ROTARIX (oral), lot number not provided. On 23 February 2008, 5 months after vaccination with 2nd dose of ROTARIX, the subject experienced bloody stools like current jelly stool with liquid diarrhea and vomiting. On 26 February 2008, the subject was hospitalised for 6 days. The physical examination showed pallor with dehydration, pharyngeal hyperemia and abdominal distension without peristalsis. The abdominal X-ray revealed dilated bowel loops with air fluid levels and lack of air in the distal colon. Barium enema was performed three times and showed a filling defect in the transverse colon, without a successful desinvagination. A surgery was performed and an ileocecocolic intussusception was found and reduced by taxis without complication. Furthermore, meckel diverticulum was observed in the distal ileon. The subject was treated with ceftriaxone, Ranitidine and Metamizole. ON 2 March 2008, the events were resolved and the subject was discharged from hospital in good clinical condition. The physician considered the events were unrelated to vaccination with ROTARIX.
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