Write-up: Information has been received from a physician concerning a female with no pertinent medical history or drug allergies who on approximately 01-AUG-2007 was vaccinated with a dose of Zostavax (Oka/Merck) in the deltoid. Concomitant drug therapy included cetrizine hydrochloride (ZYRTEC), ranitidine HCl (ZANTAC) and epinephrine (EPI-PEN). On approximately 30-SEP-2007 the patient experienced anaphylaxis characterized by chronic hives primarily on the extremities and swelling of the laryngeal area. The physician was consulted and the patient and was subsequently hospitalized for 4-5 days. Epinephrine was administered to treat the reaction. The patient was also treated with steroids for awhile. Lab diagnostic studies performed included full biochemistry labs at the hospital, electrolyte test revealing abnormalities, and a 63-64 value for lymphocyte count. The patient was noted to functional but not recovered. There was no product quality complaint. The physician considered hives and laryngeal swelling to be immediately life-threatening, disabling and an other important medical event. Additional information has been requested.