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This is VAERS ID 174275

Case Details

VAERS ID: 174275 (history)  
Form: Version 1.0  
Age: 5.0  
Sex: Female  
Location: Foreign  
   Days after vaccination:3
Submitted: 2001-08-03
   Days after onset:662
Entered: 2001-08-14
   Days after submission:11
Vaccin­ation / Manu­facturer Lot / Dose Site / Route

Administered by: Unknown       Purchased by: Unknown
Symptoms: Alanine aminotransferase increased, Anaemia, Anorexia, Aspartate aminotransferase increased, Cardio-respiratory arrest, Dehydration, Diarrhoea, Hyperaemia, Hyperbilirubinaemia, Hyperchromic anaemia, Hypochromic anaemia, Hypotension, Infection, Interstitial lung disease, Laboratory test abnormal, Prostration, Pruritus genital, Pyrexia, Respiratory distress, Tachypnoea, Vomiting, Vulval disorder
SMQs:, Torsade de pointes/QT prolongation (broad), Liver related investigations, signs and symptoms (narrow), Cholestasis and jaundice of hepatic origin (narrow), Anaphylactic reaction (narrow), Acute pancreatitis (narrow), Asthma/bronchospasm (broad), Haematopoietic erythropenia (broad), Hyperglycaemia/new onset diabetes mellitus (broad), Interstitial lung disease (narrow), Neuroleptic malignant syndrome (broad), Anticholinergic syndrome (broad), Arrhythmia related investigations, signs and symptoms (broad), Shock-associated circulatory or cardiac conditions (excl torsade de pointes) (narrow), Pseudomembranous colitis (broad), Acute central respiratory depression (broad), Biliary system related investigations, signs and symptoms (narrow), Biliary tract disorders (narrow), Gastrointestinal nonspecific symptoms and therapeutic procedures (narrow), Eosinophilic pneumonia (broad), Hypersensitivity (broad), Noninfectious diarrhoea (narrow), Respiratory failure (narrow), Drug reaction with eosinophilia and systemic symptoms syndrome (broad), Infective pneumonia (broad), Dehydration (narrow), Hypokalaemia (broad)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 1999-10-16
   Days after onset: 5
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? No
ER or Doctor Visit? No
Hospitalized? Yes, ? days
   Extended hospital stay? No
Previous Vaccinations:
Other Medications:
Current Illness:
Preexisting Conditions: Aseptic meningitis; bronchitis; diarrhea; low birth weight
Diagnostic Lab Data: Biopsy-diffuse interstitial infiltrate; neurological exam of CSF-nml: WBC-12,000/L; hematocrit-34%; serum aspartate aminotransferase-114 IU/L; total serum bilirubin-18.8 umol/L; serum immunoglobulin M test-neg. WBC count 12000. Post-mortem bx-histopathological exam revealed changes consistent with those seen in wild-type yellow fever; serum protein electrophoresis was positive for yellow fever virus
CDC Split Type: WAES01077925

Write-up: Information has been received from a physician concerning a 5 year old white female who on 10/8/99 was vaccinated with MMRII and was given a simultaneous but separate vaccine of yellow fever virus vaccine live. Three days, post vax, the pt developed a fever (39.6C) and diarrhea, and the next day, anorexia, vomiting and vulva pruritus and was seen in the ER. On exam, the pt was tachypenic, had a hyperemic pharynx, was anemic (hematocrit 34%) and had raised serum aminotransferase concentrations (aspartate aminotransferase 114 IU/L, alanine aminotransferase 160 IU/L), bilirubin concentration was slightly raised (18.9 umol/L). On the 4th day, the pt had prostration, respiratory distress, increased vomiting and diarrhea, dehydration and scleral icterus. Abdominal exam revealed enlarged, tender liver. Possible meningismus was noted. Differential dx of pneumonia and meningitis was added. CSF exam was normal. CXR revealed diffuse interstitial infiltrate in the left lung. The hematocrit fell to 30%, total leucocyte count was 12,000/L. The next day, the pt was admitted to ICU and was hypotensive, not perfusing, cyanotic, in acute respiratory distress. The pt had a cardiorespiratory arrest, was resuscitated but died within the next hour. On 10/16/99, the pt died. The cause of death was yellow fever. A meeting of yellow fever experts was convened in May 2000 and the panel unanimously concluded that the vaccine virus was the probable cause of fatal infections, which closely resembled wild-type yellow fever. Additional information is not expected.

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