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This is VAERS ID 167085

Case Details

VAERS ID: 167085 (history)  
Form: Version 1.0  
Age: 1.5  
Sex: Male  
Location: Foreign  
Vaccinated:2001-02-21
Onset:2001-02-23
   Days after vaccination:2
Submitted: 2001-03-08
   Days after onset:13
Entered: 2001-03-15
   Days after submission:7
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. 0615J / UNK - / SC

Administered by: Unknown       Purchased by: Unknown
Symptoms: Agitation, Bacterial infection, Blood pressure decreased, Brain oedema, Disseminated intravascular coagulation, Hepatomegaly, Hypotension, Hypoxia, Leukocytosis, Liver function test abnormal, Pyrexia, Sepsis
SMQs:, Liver related investigations, signs and symptoms (narrow), Anaphylactic reaction (broad), Asthma/bronchospasm (broad), Haemorrhage terms (excl laboratory terms) (narrow), Neuroleptic malignant syndrome (broad), Anticholinergic syndrome (broad), Dementia (broad), Embolic and thrombotic events, vessel type unspecified and mixed arterial and venous (narrow), Acute central respiratory depression (broad), Pulmonary hypertension (broad), Noninfectious encephalitis (broad), Noninfectious encephalopathy/delirium (broad), Noninfectious meningitis (broad), Hyponatraemia/SIADH (broad), Hostility/aggression (broad), Haemodynamic oedema, effusions and fluid overload (narrow), Cardiomyopathy (broad), Eosinophilic pneumonia (broad), Respiratory failure (broad), Drug reaction with eosinophilia and systemic symptoms syndrome (narrow), Hypoglycaemia (broad), Infective pneumonia (broad), Dehydration (broad), Hypokalaemia (broad), Sepsis (narrow)

Life Threatening? No
Birth Defect? No
Died? Yes
   Date died: 2001-02-25
   Days after onset: 2
Permanent Disability? No
Recovered? No
Office Visit? No
ER Visit? Yes
ER or Doctor Visit? No
Hospitalized? Yes, ? days
   Extended hospital stay? No
Previous Vaccinations:
Other Medications: UNK
Current Illness:
Preexisting Conditions: UNK
Allergies:
Diagnostic Lab Data: BP-50/30; temp-35C; pertinent blood results from this hospital were: WBC-33,000,000/liter (leukocytosis); lymphocytes-56%; neutrophils 34%; monocytes 9%; basophils 1%; "deranged" liver function tests; Nml ammonia and blood cultures showed coagulase neg staphylococci indentified as being skin contaminants; post mortem was being conducted on 2/25/01.
CDC Split Type: WAES01030189

Write-up: Information was received from a health professional concerning an 18 month old male who on 02/21/01, in the afternoon, was vaccinated with the MMRII. On 02/23/01, at 3 AM he was found in his bed "having a fit" with a temp of 40 degrees C. He was admitted to the hospital where he deteriorated rapidly. At 7:20 AM he was transferred to the pediatric ICU at another hospital. During his transfer, the child deteriorated and was described as "flat" and essentially brain dead on arrival. The anaesthetist suspected the patient may have "coned" (coning: axial displacement of the cerebellar tonsils through the foramen magnum) at that point. He was resuscitated by treatment with inotropes, antibiotics and ventilation. He had overwhelming sepsis with DIC. He was ventilated from 02/24/01 in the AM. On 02/25/01 the ventilator was switched off and the patient died. The cause of death was bacterial sepsis and disseminated intravascular coagulopathy. A post mortem was being conducted on 02/26/01. This information was received by Aventis Pasteur MSD manufacturer # UK011318. On F/U, the post mortem conducted on 2/26/01 revealed large swollen liver, clear meninges and a swollen brain. The cause of death was established as sepsis and a microscopic exam of the lung showed a 2 day old bronchopneumonic condition. No organism has yet been identified. It was reported that the family history is significant for a similar episode in sibling (did not report if related to a certain vaccination). The mother had 5 pregnancies, of which only 2 children remain. One was a stillbirth at term. One was a 4.5 year old child who died during a "fit" of a very rare degenerative brain condition (Otoharan syndrome). This is an amended report. The batch number HK45610 has been added to the narrative.


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