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Found 928 cases where Symptom is Idiopathic t hrombocytopenic purpura or Thrombocytopenia or Th rombocytopenic purpura and Vaccination Date on/after '2006-06-01'

Case Details

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VAERS ID: 266417 (history)  
Age: 0.18  
Gender: Female  
Location: Hawaii  
Vaccinated:2006-06-27
Onset:2006-06-29
   Days after vaccination:2
Submitted: 2006-11-07
   Days after onset:131
Entered: 2006-11-09
   Days after submission:2
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
DTAPHEPBIP: DTAP + HEPB + IPV (PEDIARIX) / GLAXOSMITHKLINE BIOLOGICALS AC21B051AA / 0 RL / IM
HIBV: HIB (ACTHIB) / SANOFI PASTEUR UE849AA / 0 LL / IM
PNC: PNEUMO (PREVNAR) / PFIZER/WYETH A25965K / 0 LL / IM

Administered by: Unknown       Purchased by: Public
Symptoms: Anaemia, Aspiration, Blindness, Blood triglycerides increased, Convulsion, Crying, Cytomegalovirus antibody positive, Deafness bilateral, Decreased appetite, Depressed level of consciousness, Developmental delay, Dysphagia, Electroencephalogram abnormal, Encephalopathy, Feeding disorder neonatal, Gastrointestinal tube insertion, Impaired healing, Laboratory test abnormal, Lethargy, Limb injury, Neurodevelopmental disorder, Polymerase chain reaction, Respiratory distress, Somnolence, Thrombocytopenia, Vomiting, White blood cell count decreased
SMQs:, Anaphylactic reaction (broad), Acute pancreatitis (broad), Dyslipidaemia (narrow), Haematopoietic erythropenia (broad), Haematopoietic leukopenia (narrow), Haematopoietic thrombocytopenia (narrow), Hyperglycaemia/new onset diabetes mellitus (broad), Neuroleptic malignant syndrome (broad), Systemic lupus erythematosus (narrow), Anticholinergic syndrome (broad), Dementia (broad), Convulsions (narrow), Acute central respiratory depression (broad), Guillain-Barre syndrome (broad), Noninfectious encephalitis (broad), Noninfectious encephalopathy/delirium (narrow), Noninfectious meningitis (broad), Accidents and injuries (narrow), Gastrointestinal nonspecific symptoms and therapeutic procedures (narrow), Glaucoma (broad), Optic nerve disorders (broad), Retinal disorders (broad), Depression (excl suicide and self injury) (broad), Hearing impairment (narrow), Lipodystrophy (broad), Hypotonic-hyporesponsive episode (broad), Generalised convulsive seizures following immunisation (narrow), Chronic kidney disease (broad), Hypersensitivity (broad), Respiratory failure (narrow), Drug reaction with eosinophilia and systemic symptoms syndrome (broad), Hypoglycaemia (broad)

Life Threatening? No
Died? No
Permanent Disability? Yes
Recovered? No
ER or Doctor Visit? No
Hospitalized? Yes, 25 days
   Extended hospital stay? Yes
Previous Vaccinations:
Other Medications: NONE
Current Illness:
Preexisting Conditions: Maternal substance abuse, history of some feeding problems at 1 month. Birth HX: 36 wk gestation; c section for breech delivery & premature ROM; Mom w/drug dependency & in rehab w/patient; delivery apgars 3/8/9.
Diagnostic Lab Data: LP 2 WBC 259 CBC glucose 59 part 43 CSF CX negative PCR for HSV, Enterovirus negative Urine CMV, EBV, HIV all negative CMV titer IgG positive IgM negative, Head CT negative MRI/Brain negative, Metabolic work up positive LABS: all cultures initially neg. MRI was WNL. EEG with mild encephalopathic process.
CDC Split Type:

Write-up: Seen on 6/27/06 for well child visit 2 months. Immunization given as below. 2 days later pt with decrease alter. Increase sleep and decreased feeding. 3 days later still with decreased feeding and decrease alert. Emesis x 1. Father reports seizure activity 3 seizures over 3 days. Pt seen in ER 7/2/06 admitted a extensive work up. No obvious cause. Still encephalopathic. Does not open eyes often. Some severe developmental delays. 12/19/06 Received hospital records which reveal patient admitted 7/2/06-7/27/06 following acute onset of lethargy, poor feeding, vomiting & seizure activity. Neuro, heme, genetic, ophthal, plastic surgery & wound care consults included. Patient on NG tube feeds due to aspiration concerns. Final Dx: Seizures; respiratory distress; dysphagia leading to aspiration; anemia; thrombocytopenia; triglyceridemia; right foot wound secondary to acyclovir infiltration; mild bilateral hearing loss; developmentally delayed; possible vision loss. Since seizure activity began 2 days s/p 2 mo vax, removal of pertussis in future vax was recommended. 1/4/2010 Severe developmental delay. Head lay, does not sit, or roll, cries but does not vocalize.


VAERS ID: 267885 (history)  
Age: 1.02  
Gender: Female  
Location: Virginia  
Vaccinated:2006-11-03
Onset:2006-11-25
   Days after vaccination:22
Submitted: 2006-11-28
   Days after onset:3
Entered: 2006-11-28
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
FLU3: INFLUENZA (SEASONAL) (FLUZONE) / SANOFI PASTEUR U2247AA / 0 RA / -
MMRV: MEASLES + MUMPS + RUBELLA + VARICELLA (PROQUAD) / MERCK & CO. INC. 1123F / 0 RA / -
PNC: PNEUMO (PREVNAR) / PFIZER/WYETH B08646F / 3 LA / -

Administered by: Private       Purchased by: Private
Symptoms: Laboratory test abnormal, Thrombocytopenia
SMQs:, Haematopoietic thrombocytopenia (narrow), Systemic lupus erythematosus (broad), Drug reaction with eosinophilia and systemic symptoms syndrome (broad)

Life Threatening? No
Died? No
Permanent Disability? No
Recovered? No
ER or Doctor Visit? No
Hospitalized? No
Previous Vaccinations:
Other Medications:
Current Illness: None
Preexisting Conditions: None
Diagnostic Lab Data: CBC Platelets <100,000 (2 times). Referred to hematology today.
CDC Split Type:

Write-up: Thrombocytopenia following MMR injection.


VAERS ID: 268287 (history)  
Age: 21.0  
Gender: Female  
Location: Massachusetts  
Vaccinated:2006-09-25
Onset:0000-00-00
Submitted: 2006-11-30
Entered: 2006-12-05
   Days after submission:5
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
HPV4: HPV (GARDASIL) / MERCK & CO. INC. 0688F / - UN / IM

Administered by: Other       Purchased by: Other
Symptoms: Epistaxis, Headache, Platelet count decreased, Thrombocytopenia
SMQs:, Haematopoietic thrombocytopenia (narrow), Haemorrhage terms (excl laboratory terms) (narrow), Systemic lupus erythematosus (broad), Drug reaction with eosinophilia and systemic symptoms syndrome (broad)

Life Threatening? Yes
Died? No
Permanent Disability? No
Recovered? Yes
ER or Doctor Visit? Yes
Hospitalized? Yes, 0 days
   Extended hospital stay? No
Previous Vaccinations:
Other Medications: NONE
Current Illness:
Preexisting Conditions: Idiopathic thrombocytopenic purpura.
Diagnostic Lab Data: Head computed axial 9/6 unspecified, spinal tap 9/06 results unspecified. Platelet count 9/06 43000
CDC Split Type: WAES0611USA06464

Write-up: Information has been received from a physician concerning a 21 year old female with no history of drug reactions/allergies, and a history of idiopathic thrombocytopenic purpura who on 9/25/06 was vaccinated IM with HPV vaccine (Lot 653735/0688F). There was no concomitant medications. In Sept 2006, a few days after vaccination the pt experienced a headache, nose bleed and developed thrombocytopenia. The pts platelet count on an unspecified date was 43,000. The pt was hospitalized and received platelet transfusion. A CT of the head and lumbar puncture were performed, however the results were unspecified. The pt subsequently recovered on an unspecified date. The reporting physician felt that one or more of the events was an other important medical event (OMIC) and life threatening. Additional Information has been requested.


VAERS ID: 268676 (history)  
Age: 1.06  
Gender: Male  
Location: Michigan  
Vaccinated:2006-12-06
Onset:2006-12-07
   Days after vaccination:1
Submitted: 2006-12-11
   Days after onset:4
Entered: 2006-12-11
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
FLU3: INFLUENZA (SEASONAL) (FLUZONE) / SANOFI PASTEUR U2199AA / 0 RL / IM
HEPA: HEP A (HAVRIX) / GLAXOSMITHKLINE BIOLOGICALS AHAVB099CB / 0 LL / IM
PNC: PNEUMO (PREVNAR) / PFIZER/WYETH B08655C / 3 LL / IM

Administered by: Unknown       Purchased by: Unknown
Symptoms: Contusion, Petechiae, Platelet count decreased, Thrombocytopenia, White blood cell count increased
SMQs:, Haematopoietic thrombocytopenia (narrow), Haemorrhage terms (excl laboratory terms) (narrow), Neuroleptic malignant syndrome (broad), Systemic lupus erythematosus (broad), Accidents and injuries (narrow), Drug reaction with eosinophilia and systemic symptoms syndrome (broad)

Life Threatening? Yes
Died? No
Permanent Disability? No
Recovered? Yes
ER or Doctor Visit? No
Hospitalized? Yes, 2 days
   Extended hospital stay? No
Previous Vaccinations:
Other Medications:
Current Illness:
Preexisting Conditions: Birth Hx: 39 wks, SVD, 8 lbs, 14 oz, no complications. Family hx: sibling with neurofibromatosis. Father with heart murmur. PMH: recurent yeast infections
Diagnostic Lab Data: 12/8/06 platelets of 17,000, segs 46, lymphs 40.
CDC Split Type:

Write-up: Thrombocytopenia, with platelet count of 17,000, developed on Dec. 7. Patient had received vaccines on Dec. 6. 12/14/06 Received medical records from provider which reveal hospital labs of 12/8/06 with platelets of 17,000, segs 46, lymphs 40 compatible with ITP. 1/2/07 Received hospital medical records which reveal patient admitted 12/8/06 with spontaneous bruising & petechiae. Improved & d/c to home 12/10 w/heme f/u. No d/c summary available. HPI: diarrhea several days prior to admission, bruising/petechiae 1 day prior to admission on forehead, neck, arms, legs abdomen & buttocks. Patient had been seen by PCP 2 days prior to admit for well child vs & given vax. Took back to PCP & CBC revealed WBC of 8.72, plts 17,000, 46 % segs, 1% bands, 40% lymphs, 6% monos, 1% eos. ADMIT DX: probable ITP idiopathic thrombocytopenic purpura.


VAERS ID: 269021 (history)  
Age: 3.0  
Gender: Male  
Location: Missouri  
Vaccinated:2006-11-03
Onset:2006-11-17
   Days after vaccination:14
Submitted: 2006-12-13
   Days after onset:26
Entered: 2006-12-18
   Days after submission:5
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
FLU3: INFLUENZA (SEASONAL) (FLUZONE) / SANOFI PASTEUR U2239AA / 4 LL / IM

Administered by: Unknown       Purchased by: Unknown
Symptoms: Contusion, Platelet count decreased, Thrombocytopenic purpura
SMQs:, Haematopoietic thrombocytopenia (narrow), Haemorrhage terms (excl laboratory terms) (narrow), Systemic lupus erythematosus (broad), Accidents and injuries (narrow), Drug reaction with eosinophilia and systemic symptoms syndrome (broad)

Life Threatening? No
Died? No
Permanent Disability? No
Recovered? No
ER or Doctor Visit? Yes
Hospitalized? No
Previous Vaccinations:
Other Medications: Claritin
Current Illness:
Preexisting Conditions:
Diagnostic Lab Data:
CDC Split Type: 200603394

Write-up: Seriousness criteria other medically significant (OMIC). Initial report received on 05 December 2006 from a health care professional. A three year old male patient, with no pre existing medical history, had received an intramuscular, left thigh injection of Fluzone, lot number U2239AA, on 03 November 2006. He had previously received four doses of influenza vaccine with no reported adverse effect. Other medications included Claritin as needed. Two weeks post vaccination, the patient developed bruising. Seventeen days later, laboratory testing showed a decreased platelet count of 19,000. The patient was diagnosed with idiopathic thrombocytopenic purpura. At the time of this report, the patient had not recovered. Additional medically relevant information was not provided.


VAERS ID: 269343 (history)  
Age: 1.28  
Gender: Male  
Location: New York  
Vaccinated:2006-12-05
Onset:2006-12-06
   Days after vaccination:1
Submitted: 2006-12-16
   Days after onset:10
Entered: 2006-12-19
   Days after submission:3
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. 0699F / 0 LA / SC
VARCEL: VARICELLA (VARIVAX) / MERCK & CO. INC. 0442F / 0 RA / SC

Administered by: Private       Purchased by: Unknown
Symptoms: Contusion, Diarrhoea, Ecchymosis, Epistaxis, Fall, Gastroenteritis, Platelet count decreased, Pyrexia, Thrombocytopenia, Vomiting, White blood cell disorder
SMQs:, Acute pancreatitis (broad), Haematopoietic leukopenia (broad), Haematopoietic thrombocytopenia (narrow), Haemorrhage terms (excl laboratory terms) (narrow), Neuroleptic malignant syndrome (broad), Systemic lupus erythematosus (broad), Anticholinergic syndrome (broad), Pseudomembranous colitis (broad), Accidents and injuries (narrow), Gastrointestinal nonspecific symptoms and therapeutic procedures (narrow), Noninfectious diarrhoea (narrow), Drug reaction with eosinophilia and systemic symptoms syndrome (broad)

Life Threatening? No
Died? No
Permanent Disability? No
Recovered? Yes
ER or Doctor Visit? Yes
Hospitalized? Yes, 1 days
   Extended hospital stay? No
Previous Vaccinations:
Other Medications:
Current Illness:
Preexisting Conditions: Post viral illness
Diagnostic Lab Data: WBC 15.6, Plt 4 WBC 15.9, Plt 770, Neutrophil 42.0, monocytes 17.0.
CDC Split Type:

Write-up: Infant started with bleeding from nose lasted 1 hr also had minor fall sustained large ecchymosis and multiple unexplained other bruises to body (ITP). 01/08/07-records received and reviewed. DOS 12/8-12/9/06 DX: ITP. PMH: acute viral GE approximately 2 weeks ago. Bruising present on head, arms, legs, trunk Treated with IVIG. Admitted subsequently 12/14-12/15/06- DC DX: acute gastroenteritis. History of vomiting and diarrhea. Temp 102.8. Treated with IVF


VAERS ID: 271488 (history)  
Age: 1.02  
Gender: Male  
Location: Michigan  
Vaccinated:2006-10-04
Onset:2006-11-15
   Days after vaccination:42
Submitted: 0000-00-00
Entered: 2007-01-30
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
HIBV: HIB (PEDVAXHIB) / MERCK & CO. INC. - / - - / -
MMRV: MEASLES + MUMPS + RUBELLA + VARICELLA (PROQUAD) / MERCK & CO. INC. - / - - / -

Administered by: Private       Purchased by: Private
Symptoms: Full blood count, Idiopathic thrombocytopenic purpura, Platelet count decreased, Thrombocytopenia
SMQs:, Haematopoietic thrombocytopenia (narrow), Haemorrhage terms (excl laboratory terms) (narrow), Systemic lupus erythematosus (broad), Hypersensitivity (narrow), Drug reaction with eosinophilia and systemic symptoms syndrome (broad)

Life Threatening? No
Died? No
Permanent Disability? No
Recovered? No
ER or Doctor Visit? No
Hospitalized? Yes, 5 days
   Extended hospital stay? No
Previous Vaccinations:
Other Medications: NONE Meds: Flintstones MVI.
Current Illness: Herpangina
Preexisting Conditions: NONE PMH: Hand, Foot, & Mouth disease 1 month prior, reflux. Allergies: NKA.
Diagnostic Lab Data: Complete blood count. Multiple labs are showing low platelets. Lowest was 10,000. Labs and Diagnostics: CBC significant for Platelets of 10,000 upon 1st admission, and from 20,000 to 120,000 during 1st hospitalization and from 18,000 to 52,000 on 2nd admission., WBC 9.9, Hgb. 12.1 and Hct. 24.8 on admission which dropped to 8.5 and 25.2 after Rhogam. Chemistry- normal. PT, PTT, INR WNL, G&T (O+)with antibody screen negative. Blood cultures negative. Labs and Diagnostics: Frequently repeated CBCs from 11/15/2006-1/10/2007 show platelet counts from 7000 to 254000, most frequently less than 50000. WBCs repeatedly low as well. Several instances of low Hgb.
CDC Split Type:

Write-up: MMR-V Proquad is given on 10/4/06 with Hib. After one month, he developed thromboycytopenia treated for idiopathic thrombocytopenia purpura. Due to persisted thrombocytopenia most likely reason is vaccine associated thrombocytopenia. 02/06/2007: MR received from 2 hospital admissions for easy bruising related to low platelets which had been occuring for approximately 2 weeks. No epistaxis or other bleeding noted. Sent to ER from Pediatrician''s office where platelet count was found to be 7000. He was admitted and treated with Rhogam. Two weeks later he was re-admitted for increased bruising again and treated with IgG. PE: WNL except multiple areas of ecchymosis of lower extremities, chest, forearms, and face on both admissions. Petechia noted on face, arms, legs, and buttocks on 11/16/06. Discharge DX on 11/18/2006: Idiopathic thrombocytopenic purpura. Discharge DX on 11/29/2006: 1) Thrombocytopenia IgG 2) Anemia. 02/19/2007: MR received from PCP. Infant in for 1 yr. check-up on 10/04/2006 with c/o sores in mouth and recurrent rash x several days. Fever for 2 days noted, now doing well. Child with DX: of Herpangina given Proquad and Pedvax. Seen again 10/25/2006 for cold sx. and conjunctivitis. Several hospital F/Us for ITP with repeated labs. DX: ITP.


VAERS ID: 271868 (history)  
Age: 11.0  
Gender: Female  
Location: Virginia  
Vaccinated:2006-08-02
Onset:2006-11-07
   Days after vaccination:97
Submitted: 2007-02-05
   Days after onset:90
Entered: 2007-02-06
   Days after submission:1
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
TDAP: TDAP (ADACEL) / SANOFI PASTEUR - / 0 LL / -

Administered by: Unknown       Purchased by: Unknown
Symptoms: Contusion, Epistaxis, Idiopathic thrombocytopenic purpura, Petechiae, Platelet count decreased, Red blood cell count decreased, Red blood cells urine positive, Urobilin urine absent, White blood cell count normal
SMQs:, Liver related investigations, signs and symptoms (broad), Haematopoietic erythropenia (narrow), Haematopoietic thrombocytopenia (narrow), Haemorrhage terms (excl laboratory terms) (narrow), Haemorrhage laboratory terms (broad), Systemic lupus erythematosus (broad), Biliary system related investigations, signs and symptoms (broad), Accidents and injuries (narrow), Chronic kidney disease (broad), Hypersensitivity (narrow), Tubulointerstitial diseases (broad), Drug reaction with eosinophilia and systemic symptoms syndrome (broad)

Life Threatening? Yes
Died? No
Permanent Disability? No
Recovered? No
ER or Doctor Visit? Yes
Hospitalized? Yes, 3 days
   Extended hospital stay? No
Previous Vaccinations:
Other Medications:
Current Illness: none
Preexisting Conditions: none HX of Lyme disease several years ago.
Diagnostic Lab Data: Plateletes have jumped up and down 7000, 9000, 77000, 7900, 14000, 125000, 7000, 25800 while on Win Rho and two weeks later 21000 Red and white blood cells normal Red has dropped a little after Win Rho. Labs: IbA 204. Labs: Platelets range from 172 to 7. Granulocytes 47, basophils 2, myelocytes 1.Urine dipstick positive for blood with 6-8 REBC and then repeats with 0-2 RBC, urobilinogen ws negative times two. After WinRho platelets 25000 and subsequent day platelets 133000 and was discharged. EBV negative. IGG 1.91 Parainfluenza 1 AB IGG 2.19 Parainfluenza A AB IGM 0.68 Parainfluenza 3 AB IGG 1.56 CMV AB IGM 0.53.
CDC Split Type:

Write-up: In September my daughter started getting bruises on her arms and legs. Everytime we asked how she got them she would reply that she bumped into a table or something. Having 4 children bruising is not so strange. She is in Martial Arts and has contact in class. This started out less obvious and little by little got more obvious. By October I noticed one day that she had major bruises on her arms and I immediately called her Doctor but after talking to him and he telling me to bring her in to get blood work I realized that she had participated in a Martial Arts tournament and went up against a 3rd degree black belt and felt that is where she recieved the bruises so I called the Doctor back and he told me to watch them. Well after a week went by I noticed that she had more bruises and they were really getting bigger. I then called him and he told me to come in for blood work. I took her in on Nov 5th and they sent me to the hospital to get the bloodwork done but when I got to the hospital they had left for the day so I returned the next morning. I got a call later that the blood work did not turn out to bring her in again which I did before I could get home they called and had me bring her back in due to her plateletes being at a critical level 7000 and this has been going on every since and they are calling it ITP. Now although the Doctor really does not believe that the vaccination was the start of this disorder I believe whole heartly it is He kept asking me if she had gotten any kind of virus in the month of August I kept repeating no. My daughter is now in the 6th grade and has never missed a day of school in her life that is how much she gets virus''s or sick. I know my children and I can count on one hand how many times this one has ever gotten anything and with my records at the pediatrician I do take my children to the doctor or call him when they are sick. My daughter has been on prednisone twice and Win Rho twice the first Iv medication only lasted about two weeks her plateletes continue to drop to a critical level. 02/07/07-records received and reviewed from PCP for DOS 11/10/06-2/5/07 DX: ITP Symptoms bruising. 02/13/07-records reviewed from hem/onc for DOS 02/01/07 DX: relapsing and remitting thrombocytopenia. Possibly since early September but documentation until early November. Looks like she is heading to have chronic IPT. Persistent low platelet counts. Bruising began in early September 2006, did not seek medical attention until first week in November. 11/8/06- platelets 7000 and on 11/10, 122000 and then on 11/10 79000. Child involved with martial arts. Began steroids. Hospitalized on 1/13 received WinRho at that time platelets 9000. Two nosebleed in November. PE:WNL except for some petechiae on neck. Per 60 day follow up: Bruising, petechiae, low platelets, ITP. The brusiing started at the begining of Sept. 2006, we did not get a diagnosis immediately due to not knowing anything. It is now considered chronic with no cure. She has been hospitalized on several occassions due to platelets dropping to a critical count.


VAERS ID: 271951 (history)  
Age: 4.0  
Gender: Male  
Location: Washington  
Vaccinated:2007-01-03
Onset:2007-02-04
   Days after vaccination:32
Submitted: 2007-02-08
   Days after onset:4
Entered: 2007-02-08
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
MMR: MEASLES + MUMPS + RUBELLA (MMR II) / MERCK & CO. INC. 0707F / 0 RA / SC
VARCEL: VARICELLA (VARIVAX) / MERCK & CO. INC. 0908F / 0 LA / SC

Administered by: Private       Purchased by: Public
Symptoms: Blood test, Idiopathic thrombocytopenic purpura
SMQs:, Haemorrhage terms (excl laboratory terms) (narrow), Hypersensitivity (narrow)

Life Threatening? No
Died? No
Permanent Disability? No
Recovered? No
ER or Doctor Visit? Yes
Hospitalized? No
Previous Vaccinations:
Other Medications: Started on amoxicillin day of visit for Otitis Media, Tylenol prn
Current Illness: Left Otitis Media, URI
Preexisting Conditions: None
Diagnostic Lab Data: Stable and improving. Anticipate full recovery. Undergoing frequent blood draws to monitor platelet levels
CDC Split Type:

Write-up: Diagnosed with ITP (idiopathic thrombolytic purpura) 2/4/2007, 32 days after administration of Varicella and MMR vaccines.


VAERS ID: 273706 (history)  
Age: 15.0  
Gender: Female  
Location: Unknown  
Vaccinated:2006-11-24
Onset:2006-11-24
   Days after vaccination:0
Submitted: 2007-03-08
   Days after onset:104
Entered: 2007-03-09
   Days after submission:1
Vaccin­ation / Manu­facturer Lot / Dose Site / Route
HPV4: HPV (GARDASIL) / MERCK & CO. INC. - / 1 UN / -

Administered by: Other       Purchased by: Other
Symptoms: Condition aggravated, Contusion, Idiopathic thrombocytopenic purpura, Infectious mononucleosis, Injection site haematoma, Petechiae, Platelet count increased, Platelet count normal
SMQs:, Haemorrhage terms (excl laboratory terms) (narrow), Accidents and injuries (narrow), Hypersensitivity (narrow)

Life Threatening? No
Died? No
Permanent Disability? No
Recovered? Yes
ER or Doctor Visit? No
Hospitalized? Yes, 0 days
   Extended hospital stay? No
Previous Vaccinations:
Other Medications:
Current Illness: Gingival bleeding; Heavy periods; Sore throat; Steroid therapy; infectious mononucleosis
Preexisting Conditions:
Diagnostic Lab Data: platelet count 12/12/06 $g5 150-400, platelet count 01/29/07 150-400 normal
CDC Split Type: WAES0703USA00022

Write-up: Information has been received from a physician at health conference, concerning her 15 year old daughter with a history of bleeding gums (attributed to orthodontic braces) previous 7 days, menstruation heavier 7 days earlier, slight sore throat approximately 1 week prior, and infectious mononucleosis showed possible acute infection, but seroconversion did not occur until 05-FEB-2007, possibly delayed by prolonged steroid treatment. On 03-OCT-2006, the patient was vaccinated with first dose of HPV vaccine. No reaction occurred. On 24-NOV-2006, the patient was vaccinated with second dose of HPV vaccine (lot # not reported), one month after the first dose. No reaction occurred. On 12-DEC-2006, poliovirus vaccine boosterix injection was given. A 5cm bruise developed within 4 hours. On 12-DEC-2006, the patient was hospitalized with a platelet count greater than 5. Signs included: 4 cm hematoma at the site of immunization left upper arm, few petechiae on lower abdomen, no hepato-splenomegaly. Provisional diagnosis of immune thrombocytopenia (ITP) was made. The patient was treated with Prednisone 75 mg stat, 3 weeks of 50 mg Prednisone, followed by decreasing dose over the next month. By 29-JAN-2007, the patient''s platelet count slowly returned to normal. The physician commented: "This is case of ITP, probably due to infectious mononucleosis, but diagnosed 18 days after the second dose of HPV vaccine (symptoms started approximately 10 days after the vaccine). I am hopeful it was due to Glandular fever but an interesting co-incidence and an unusual presentation of "IW." Additional information has been requested.


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